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Fetal Alcohol Exposure Alters Blood Flow and Neurological Responses to Transient Cerebral Ischemia in Adult Mice
Background: Prenatal alcohol exposure (PAE) can result in physical and neurocognitive deficits that are collectively termed “fetal alcohol spectrum disorders” (FASD). Although FASD is associated with lifelong intellectual disability, the mechanisms …
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Elastase-2, an angiotensin II-generating enzyme, contributes to increased Ang II in resistance arteries of mice with myocardial infarction.
Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme activity, mediates most of the renin-angiotensin-system effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively …
Publication
Echocardiography-Guided Intramyocardial Injection Method in a Murine Model
Cardiac regenerative therapy has received attention as a potentially revolutionary approach for treating the damaged heart. The mouse model of myocardial infarction (MI) remains one of the most common tools for the evaluation of such new therapies. …
Publication
Challenging cardiac function post-spinal cord injury with dobutamine
There is general consensus that spinal cord injuries (SCI) above T6 result in altered sympathetic control of the heart,which negatively influences cardiac structure and function. To by-pass disrupted circuitry and investigate cardiac responses under …
Publication
Original Article Differential Functional Deficits in Type 1 Versus Type 2 Diabetic Mice Models
Introduction: Types 1 and 2 diabetes have different causative mechanisms. Hence, different extent of cardiovascular, cognitive and auditory functions could be expected. Materials and methods: Body weight, blood glucose were measured in Wild type(WT), …
Publication
Maintained right ventricular pressure overload induces ventricular-arterial decoupling in mice
Assessment of right ventricular (RV) function in rodents is a challenge due to the complex RV anatomy and structure. Subsequently, the best characterization of RV function is achieved by accurate cardiovascular phenotyping, involving a combination of …
Publication
Targeting and modulating infarct macrophages with hemin formulated in designed lipid-based particles improves cardiac remodeling and function
Uncontrolled activation of pro-inflammatory macrophages after myocardial infarction (MI) accelerates adverse left ventricular (LV) remodeling and dysfunction. Hemin, an iron-containing porphyrin, activates heme oxygen- ase-1 (HO-1), an enzymewith …
Publication
Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction
Cardiac fibrosis is a common finding in patients with chronic kidney disease. Here, we investigate the cardio-renal effects of theracurmin, a novel formulation of the polyphenolic compound curcumin, in a rat model of chronic kidney disease. Briefly, …
Publication
Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction
Cardiac fibrosis is a common finding in patients with chronic kidney disease. Here, we investigate the cardio-renal effects of theracurmin, a novel formulation of the polyphenolic compound curcumin, in a rat model of chronic kidney disease. Briefly, …
Publication
Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB up-regulation and vascular remodelling
Increased production of methylglyoxal (MG) in vascular tissues is one of the causative factors for vascular remodeling in different subtypes of metabolic syndrome, including hypertension and insulin resistance. Fructose-induced upregulation of aldolase B …