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Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice
AIMS Bone morphogenetic protein (BMP) signalling plays a key role in regulating the development of the atrioventricular (AV) septum and valves; however, the molecules that mediate the complex activities of BMP signalling are not fully understood. The …
Publication
Obligatory role for GPER in cardiovascular aging and disease
Pharmacological activation of the heptahelical G protein-coupled estrogen receptor (GPER) by selective ligands counteracts multiple aspects of cardiovascular disease. We thus expected that genetic deletion or pharmacological inhibition of GPER would …
Publication
Defective branched chain amino acids catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction
Cardiac metabolic remodeling is a central event during heart failure (HF) development following myocardial infarction (MI). It is well-known that myocardial glucose and fatty acids dysmetabolism contributes to post-MI cardiac dysfunction and remodeling. …
Publication
Mitochondrial tRNA mutation with high-salt stimulation on cardiac damage: underlying mechanism associated with change of Bax and VDAC
Mitochondrial transfer RNA (tRNA) mutation with high-salt stimulation can cause high blood pressure. However, the underlying mechanisms remain unclear. In the present study, we examined the potential molecular mechanisms of cardiac damage caused by …
Publication
A conducting polymer with enhanced electronic stability applied in cardiac models
Electrically active constructs can have a beneficial effect on electroresponsive tissues, such as the brain, heart, and nervous system. Conducting polymers (CPs) are being considered as components of these constructs because of their intrinsic …
Publication
Exploring Targeted Contrast-Enhanced Ultrasound to Detect Neural Inflammation: An Example of Standard Nomenclature
Targeted contrast-enhanced ultrasound (TCEUS) is an innovative method of molecular imaging used for detection of inflammatory biomarkers in vivo. By targeting ultrasound contrast to cell adhesion molecules (CAMs), which are known inflammatory markers …
Publication
The chromatin binding protein Smyd1 restricts adult mammalian heart growth.
All terminally differentiated organs face two challenges: maintaining their cellular identity and restricting organ size. The molecular mechanisms responsible for these decisions are of critical importance to organismal development and perturbations in …
Publication
Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer
Pancreatic cancer is one of the hardest-to-treat types of neoplastic diseases. Metformin, a widely prescribed drug against type 2 diabetes mellitus, is being trialed as an agent against pancreatic cancer, although its efficacy is low. With the idea of …
Publication
Mas receptor contributes to pregnancy-induced cardiac remodelling
Previous studies have demonstrated a protective effect of the Ang-(1–7)/Mas receptor axis on pathological cardiac hypertrophy. Also, the involvement of Mas receptor in exercise-induced cardiac hypertrophy has been suggested. However, the role of the …
Publication
Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice.
Decreased heat shock protein (Hsp) expression in type-1 and type-2 diabetes has been implicated as a primary factor contributing to diabetes-induced organ damage. We recently showed that diabetic cardiomyocytes could release detrimental exosomes, which …