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Comparison between sparse and concentrated scattering models for characterization of cell-pellet biophantoms and excised mouse tumors
Three scattering models were examined for characterizing in vitro biophantoms and ex vivo colon adenocarcinoma (HT29) mouse tumors in the 10-42 MHz and the 15-42 MHz frequency bandwidth, respectively. The Spherical Gaussian Model (SGM) and the …
Publication
Wave intensity analysis in mice: age-related changes in WIA peaks and correlation with cardiac indexes
Mouse models are increasingly employed in the comprehension of cardiovascular disease. Wave Intensity Analysis (WIA) can provide information about the interaction between the vascular and the cardiac system. We investigate age-associated changes in …
Publication
Establishment of a new acute-on-chronic liver failure model
To establish an animal model of acute-on-chronic liver failure (ACLF) that would replicate the pathological process of ACLF in humans, rats were administered porcine serum (PS) for 11 weeks. Liver fibrosis was determined by pathological and biochemical …
Publication
Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart
Sympathetic stimulation modulates L-type calcium channel (LTCC) gating to contribute to increased systolic heart function. Rad is a monomeric G-protein that interacts with LTCC. Genetic deletion of Rad (Rad−/−) renders LTCC in a sympathomimetic state. The …
Publication
A practical approach to remote ischemic preconditioning and ischemic preconditioning against myocardial ischemia/reperfusion injury
Although urgently needed in clinical practice, a cardioprotective therapeutic approach against myocardial ischemia/ reperfusion injury remains to be established. Remote ischemic preconditioning (rIPC) and ischemic preconditioning (IPC) represent promising …
Publication
The role of transient receptor potential vanilloid 2 channel in cardiac aging
Background The aging heart is characterized by cellular and molecular changes leading to a decline in physiologic function and cardiac remodeling, specifically the development of myocyte hypertrophy and fibrosis. Transient receptor potential vanilloid 2 …
Publication
Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction
Rationale: Phosphodiesterase 2 (PDE2) is a dual substrate esterase, which has the unique property to be stimulated by cGMP, but primarily hydrolyses cAMP. Myocardial PDE2 is upregulated in human heart failure (HF), but its role in the heart is unknown. …
Publication
Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations
Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nu- clear lamina alterations, severe cardiovascular pathology, and pre- mature death. Prelamin A alterations also occur in …
Publication
VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection
Congestive heart failure is one of the leading causes of disability in long-term survivors of cancer. The anthracycline antibiotic doxo- rubicin (DOX) is used to treat a variety of cancers, but its utility is limited by its cumulative cardiotoxicity. As …
Publication
Congenital valvular defects associated with deleterious mutations in the PLD1 gene
BACKGROUND The underlying molecular aetiology of congenital heart defects is largely unknown. The aim of this study was to explore the genetic basis of non-syndromic severe congenital valve malformations in two unrelated families. METHODS Whole-exome …