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Publication
Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction
Left ventricular (LV) remodel- ing, after myocardial infarction (MI), can result in LV dilation and LV pump dysfunction. Post-MI induction of matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, have been implicated as causing deleterious …
Publication
Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance
To determine whether Nordic walking improves cardiovascular function in middle-aged women and men, we included 121 with normal glucose tolerance, 33 with impaired glucose tolerance and 47 with Type 2 diabetes mellitus in a randomized controlled study. The …
Publication
Chronic Exposure to Bisphenol A Reduces Successful Cardiac Remodeling After an Experimental Myocardial Infarction in Male C57bl/6n Mice
Estrogenic compounds such as bisphenol A (BPA) leach from plastics into food and beverage containers. Increased BPA exposure has been correlated with increased cardiovascular disease. To test the hypothesis that increased BPA exposure reduces …
Publication
Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis
The development of heart failure is associated with changes in the size, shape, and structure of the heart that has a negative impact on cardiac function. These pathological changes involve excessive extracellular matrix deposition within the myocardial …
Publication
Accuracy of ultrasound-guided intra-articular injections in guinea pig knees
OBJECTIVE: Dunkin Hartley guinea pigs, a commonly used animal model of osteoarthritis, were used to determine if high frequency ultrasound can ensure intra-articular injections are accurately positioned in the knee joint. METHODS: A high-resolution small …
Publication
Quantitative correlational study of microbubble-enhanced ultrasound imaging and magnetic resonance imaging of glioma and early response to radiotherapy in a rat model
Purpose: Radiotherapy remains a major treatment method for malignant tumors. Magnetic reso- nance imaging (MRI) is the standard modality for assessing glioma treatment response in the clinic. Compared to MRI, ultrasound imaging is low-cost and portable …
Publication
Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia
Aims In myocardial ischaemia, vascular endothelial growth factor (VEGF) induces permeability by activating a signalling path- way that includes VEGF receptor 2 (VEGFR2), resulting in increased oedema and inflammation and thereby expanding the area of …
Publication
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase ( Txnrd2 ) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium
Background-—Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal and associated with abnormal heart development, while constitutive, heart-specific Txnrd2 inactivation leads to dilated cardiomyopathy and perinatal death. …
Publication
The intracellular domains of Notch1 and 2 are functionally equivalent during development and carcinogenesis
Although Notch1 and Notch2 are closely related paralogs and function through the same canonical signaling pathway, they contribute to different outcomes in some cell and disease contexts. To understand the basis for these differences, we examined in …
Publication
Tolerance to ischaemic injury in remodelled mouse hearts: less ischaemic glycogenolysis and preserved metabolic efficiency
Aims Post-infarction remodelled failing hearts have reduced metabolic efficiency. Paradoxically, they have increased toler- ance to further ischaemic injury. This study was designed to investigate the metabolic mechanisms that may contribute to this …