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Murine Double Minute-2 Inhibition Attenuates Cardiac Dysfunction and Fibrosis by Modulating NF-κB Pathway After Experimental Myocardial Infarction
Abstract—Inflammation has been implicated in myocardial infarction (MI). MDM2 associates with n- uclear factor-κB(NF-κB)-mediated inflammation. However, the role ofMDM2 inMI remains unclear. This study aimed to evaluate the impacts ofMDM2 inhibition on …
Publication
Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism
Qishen granules (QSG), a traditional Chinese medicine, have been prescribed widely in the treatment of coronary heart diseases. Previous studies demonstrated that QSG had anti-inflammatory and cardio-protective effects in mice with acute myocardial …
Publication
Inwardly-rectifying K + channels are major contributors to flow-induced vasodilation in resistance arteries
Aims: Inwardly rectifying K+ (Kir) channels are known to be sensitive to flow, but their role in flow-induced endothelial responses is not known. The goal of this study is to establish the role of Kir channels in flow-induced vasodilation and to provide …
Publication
Aldehyde dehydrogenase 2 deficiency negates chronic low-to-moderate alcohol consumption-induced cardioprotecion possibly via ROS-dependent apoptosis and RIP1/RIP3/MLKL-mediated necroptosis
Previous studies evidenced the beneficial effects of low-to-moderate alcohol consumption on cardiovascular sys- temby activation of mitochondrial aldehyde dehydrogenase 2 (ALDH2), a key enzyme metabolizing acetalde- hyde to innocuous acetic acid, in …
Publication
An EP4 Receptor Agonist Inhibits Cardiac Fibrosis Through Activation of PKA Signaling in Hypertrophied Heart
Cardiac fibrosis is a pathological feature of myocardium of failing heart and plays causative roles in arrhythmia and cardiac dysfunction, but its regulatory mechanisms remain largely elusive. In this study, we investigated the effects of the novel EP4 …
Publication
Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration
Heart attack is a global health problem that leads to significant morbidity, mortality, and health care burden. Adult human hearts have very limited regenerative capability after injury. However, evolutionarily primitive species generally have higher …
Publication
CREG protects from myocardial ischemia/reperfusion injury by regulating myocardial autophagy and apoptosis
Aims: Human cellular repressor of E1A-stimulated genes (CREG) is a secreted glycoprotein that regulates tissue and cell homeostasis and has been shown to antagonize heart fibrosis,which indicates a potential protective effect of CREG against cardiomyocyte …
Publication
Atorvastatin Alleviates Experimental Diabetic Cardiomyopathy by Regulating the GSK-3β-PP2Ac-NF-κB Signaling Axis
Recent studies reported that atorvastatin (ATOR) alleviated progression of experimental diabetic cardiomyopathy (DCM), possibly by protecting against apoptosis. However, the underlying mechanisms of this protective effect remain unclear. Therefore, our …
Publication
Helix B surface peptide attenuates diabetic cardiomyopathy via AMPK-dependent autophagy
Background: Erythropoietin (EPO) has been reported to exert protective effects on a host of damaged tissues. However, the erythropoietic effect of this hormone can result in high risks of thrombosis, stroke, and hypertension, remarkably limiting the …
Publication
Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with survival averaging only 3months if untreated following diagnosis. A major limitation in effectively treating PDAC using conventional and targeted chemotherapeutic agents, is …