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Comparison of Arterial Input Function Models for Small-Animal Ultrasound Perfusion Imaging
Background, Motivation and Objective Bolus & burst (B&B) is a method for quantitative ultrasound perfusion analysis combining bolus tracking and burst replenishment. Estimation of perfusion parameters is based on blind deconvolution where the measured …
Publication
Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response
The Frank–Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and …
Publication
Influence of shear stress magnitude and direction on atherosclerotic plaque composition
The precise flow characteristics that promote different atherosclerotic plaque types remain unclear. We previously developed a blood flow-modifying cuff for ApoE−/− mice that induces the development of advanced plaques with vulnerable and stable features …
Publication
Resveratrol protects against lipopolysaccharide-induced cardiac dysfunction by enhancing SERCA2a activity through promoting the phospholamban oligomerization
Resveratrol protects against lipopolysaccharide-induced cardiac dysfunction by enhancing SERCA2a activity through promoting the phospholamban oligomeriza- tion. Am J Physiol Heart Circ Physiol 311: H1051–H1062, 2016. First published September 2, 2016; …
Publication
Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell retention and animal survival for in vivo stem cell therapy of myocardial infarction. Here we show that pluripotent stem cell aggregates pre-differentiated …
Publication
Toll-like receptor 4 mutation suppresses hyperhomocysteinemia-induced hypertension
Hyperhomocysteinemia (HHcy) has been observed to promote hypertension, but the mechanisms are unclear. Toll-like receptor 4 (TLR-4) is a cellular membrane protein that is ubiquitously expressed in all cell types of the vasculature. TLR-4 activation has …
Publication
Increased complements and high-sensitivity C-reactive protein predict heart failure in acute myocardial infarction
The aim of the present study was to investigate whether the serum levels of complements and high-sensitivity C-reactive protein (hs-CRP) in patients with acute myocardial infarction (AMI) are associated with the severity of myocardial injury. Consecutive …
Publication
Resveratrol Reverses Functional Chagas Heart Disease in Mice
Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of parasite burden. During disease, the heart undergoes oxidative stress, a potential …
Publication
Assessment of murine colorectal cancer by micro-ultrasound using three dimensional reconstruction and non-linear contrast imaging
The relatively low success rates of current colorectal cancer (CRC) therapies have led investigators to search for more specific treatments. Vertebrate models of colorectal cancer are essential tools for the verification of new therapeutic avenues such as …
Publication
Postinjury biomechanics of Achilles tendon vary by sex and hormone status
Achilles tendon ruptures are common injuries. Sex differences are present in mechanical properties of uninjured Achilles tendon, but it remains unknown if these differences extend to tendon healing. We hypothesized that ovariectomized females (OVX) and …