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Structural and functional photoacoustic molecular tomography aided by emerging contrast agents
Photoacoustic tomography (PAT) can offer structural, functional and molecular contrasts at scalable observation level. By ultrasonically overcoming the strong optical scattering, this imaging technology can reach centimeters penetration depth while …
Publication
Contrast Agents for Photoacoustic and Thermoacoustic Imaging: A Review
Photoacoustic imaging (PAI) and thermoacoustic imaging (TAI) are two emerging biomedical imaging techniques that both utilize ultrasonic signals as an information carrier. Unique advantages of PAI and TAI are their abilities to provide high resolution …
Publication
Biomedical Applications of Photoacoustic Imaging with Exogenous Contrast Agents
Photoacoustic imaging is a biomedical imaging modality that provides functional information, and, with the help of exogenous contrast agents, cellular and molecular signatures of tissue. In this article, we review the biomedical applications of …
Publication
Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging
Photoacoustic imaging (PAI) has the potential for real-time molecular imaging at high resolution and deep inside the tissue, using nonionizing radiation and not necessarily depending on exogenous imaging agents, making this technique very promising for a …
Publication
Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field.
Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates …
Publication
307 Orthotopic tumorgrafts in nude mice: A new method to study human prostate cancer
BACKGROUND. In vivo model systems in prostate cancer research that authentically reproduce tumor growth are still sparse. While orthotopic implantation is technically difficult, particularly in the mouse, most models favor subcutaneous tumor growth. This …
Publication
Experimental orthotopic prostate tumor in nude mice: Techniques for local cell inoculation and three-dimensional ultrasound monitoring
Objectives: Orthotopic prostate cancer models are of great importance for cancer research. Orthotopic models in mice have been described previously. However, these studies lack a detailed methodological description and fail to define standards for local …
Publication
High-Resolution Ultrasound Allows Percutaneous Initiation and Surveillance of Prostate Cancer in an Orthotopic Murine Model
Introduction: Prostate cancer xenografts should prefer or- thotopic growth to subcutaneous tumors as the former more closely mimics the natural tumor environment. However, these models are technically demanding and require an invasive laparotomy. To …
Publication
Comparative study of high-resolution microimaging with 30-MHz scanner for evaluating cardiac function in mice.
BACKGROUND: The accurate assessment of cardiac function in mice is challenging because of their small heart size and rapid heart rate.\n\nMETHODS: We examined the usefulness of novel high-resolution echocardiography (HRE) with a 30-MHz transducer in …
Publication
In Utero Exposure to a Cardiac Teratogen Causes Reversible Deficits in Postnatal Cardiovascular Function, But Altered Adaptation to the Burden of Pregnancy
Congenital heart defects (CHD) are the most common birth anomaly and while many resolve spontaneously by 1 year of age, the lifelong burden on survivors is poorly understood. Using a rat model of chemically induced CHD that resolve postnatally, we sought …