Doxorubicin-loaded hollow nanoshells (Dox@PEG-HAuNS) increases the efficacy of photothermal ablation (PTA) by not only mediating efficient PTA but also through chemotherapy, and therefore have potential utility for local anticancer therapy. However, in …

Ultrasound offers signifi cant potential as a molecular imaging modality when imaging microbubble agents owing to single-bubble sensitivity. However, these agents are typically too large to escape the vascular system. Photoacoustic imaging is a novel …

Photoacoustic imaging, frequently coregistered with ultrasonic imaging, can provide functional and cellular/ molecular information about tissue within the anatomical land- marks of an imaged region. This review details the fundamen- tals of photoacoustic …

Alterations in tumor perfusion and microenvironment have been shown to be associated with aggressive cancer phenotypes, raising the need for noninvasive methods of tracking these changes. Dynamic contrast enhanced ultrasound (DCEUS) and photoacoustic (PA) …

Polyethylene glycol (PEG) surface modification is one of the most widely used approaches to improve the solubility of inorganic nanoparticles, prevent their aggregation and prolong their in vivo blood circulation half-life. Herein, we developed …

Summary: Photoacoustic imaging imparts the ability to distinguish materials according to their differences in optical absorp- tion (ie, their color) with the high spatial and temporal resolution of ultrasonography (US). Experiments in rats show the …

Manganese dioxide (MnO 2 ) nanoparticles (NPs) were discovered in previous work to be effective in improving tumor oxygenation (hypoxia) and reducing H 2 O 2 and acidity in the tumor microenvironment (TME) via local injection. To develop MnO 2 …

Wereport quantitative photoacoustic elastography (QPAE) capable of measuring Young’s modulus of biological tissue in vivo in humans. By combining conventional PAE with a stress sensor having known stress– strain behavior, QPAE can simultaneously measure …

A simple, crude Jatropha curcas (JC) oil-based synthesis approach, devoid of any toxic phosphine and pyrophoric ligands, to produce size and shape tuned CdSe QDs and a further copper sulfide (Cu2S) encasing is presented. The QDs exhibited excellent …

Photoacoustic (PA) imaging for biomedical applications has been under development for many years. Based on the many advances over the past decade, a new photoacoustic imaging system has been integrated into a micro-ultrasound platform for co-registered …