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In vivo bioimaging as a novel strategy to detect doxorubicin-induced damage to gonadal blood vessels.
INTRODUCTION: Chemotherapy may induce deleterious effects in normal tissues, leading to organ damage. Direct vascular injury is the least characterized side effect. Our aim was to establish a real-time, in vivo molecular imaging platform for evaluating …
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Ovarian imaging in the mouse using ultrasound biomicroscopy (UBM): a validation study.
The mouse is a well accepted model for studies of human reproduction despite little being known about follicle dynamics in this species. Longitudinal studies of mouse folliculogenesis have been hampered by the lack of an appropriate imaging tool. …
Publication
Original Article Use of ultrasound biomicroscopy to evaluate induced ovarian follicular growth and ovulation in mice
Original Article Use of ultrasound biomicroscopy to evaluate induced ovarian follicular growth and ovulation in mice …
Publication
In vivo imaging of cumulus-oocyte-complexes and small ovarian follicles in cattle using ultrasonic biomicroscopy.
The objectives of this study were to: (1) evaluate the feasibility of ultrasonic biomicroscopy (UBM) for imaging ovarian follicles in vivo in cows and heifers, (2) compare the transvaginal to the transrectal approach, (3) compare the number of follicles …
Publication
Calcific aortic valve stenosis: methods, models, and mechanisms.
Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major paradigm shift in the field. CAVS was thought to be a passive, …
Publication
Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old Mice
Aging leads to a high prevalence of glucose intolerance and cardiovascular diseases, with oxidative stress playing a potential role. Resveratrol has shown promising effects on glucose tolerance and tends to improve endothelial function in elderly …
Publication
The innate immune system contributes to tissue-engineered vascular graft performance
The first clinical trial of tissue-engineered vascular grafts (TEVGs) identified stenosis as the primary cause of graft failure. In this study, we aimed to elucidate the role of the host immune response in the development of stenosis using a murine model …
Publication
A background Ca 2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling
Aims: Pathological cardiac hypertrophy is a major predictor for the development of cardiac diseases. It is associated with chronic neurohumoral stimulation and with altered cardiac Ca2+ signalling in cardiomyocytes. TRPC proteins form agonist-induced …
Publication
Multimodality and Molecular Imaging of Matrix Metalloproteinase Activation in Calcific Aortic Valve Disease
Calcific aortic valve disease (CAVD) is the most common cause of aortic stenosis. Matrix metalloproteinases (MMPs) are upregulated in CAVD and contribute to valvular remodeling and calcification. We investigated the feasibility and correlates of …
Publication
Modulation of cardiac fibrosis by Krüppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes
Aims: Kru ¨ppel-like factors (KLFs) are a family of transcription factors which play important roles in the heart under patho- logical and developmental conditions.We previously identified and cloned Klf6 whose homozygous mutation in mice results in …