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Hyperglycemia Induces Defective Ca 2+ Homeostasis in Cardiomyocytes
Diabetes and other metabolic conditions characterized by elevated blood glucose constitute important risk factors for cardiovascular disease. Hyperglycemia targets myocardial cells rendering ineffective mechanical properties of the heart, but cellular …
Publication
Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia/reperfusion injury through AMPK activation-mediated mitochondrial fission
GRS is a drug combination of three active components including ginsenoside Rb1, ruscogenin and schisandrin. It derived from the well-known TCM formula ShengMai preparations, a widely used traditional Chinese medicine for the treatment of cardiovascular …
Publication
Local checkpoint inhibition of CTLA-4 as a monotherapy or in combination with anti-PD1 prevents the growth of murine bladder cancer
ABSTRACT Checkpoint blockade of CTLA-4 results in long-lasting survival benefits in metastatic cancer patients. However, patients treated with CTLA-4 blockade have suffered from immune related adverse events, most likely due to the breadth of the induced …
Publication
Vγ1+γδT, early cardiac infiltrated innate population dominantly producing IL-4, protect mice against CVB3 myocarditis by modulating IFNγ+ T response
Viral myocarditis (VMC) is an inflammation of the myocardium closely associated with Coxsackievirus B3 (CVB3) infection. V?1+??T cells, one of early cardiac infiltrated innate population, were reported to pro- tect CVB3 myocarditis while the precise …
Publication
Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability
Locomotion is an essential animal behavior used for translocation. The spinal cord acts as key executing center, but how it coordinates many body parts located across distance remains poorly under- stood. Here we employed mouse genetic and viral …
Publication
Bcl-2–associated athanogene 3 protects the heart from ischemia/reperfusion injury
Introduction Bcl-2–associated athanogene 3 (BAG3) is a 575–amino acid protein that is highly conserved in nature (1). First identified by its ability to bind Bcl-2, BAG3 is expressed most abundantly in the heart and skeletal muscle and in many cancers. …
Publication
Validation of ultrasonography for non-invasive assessment of diaphragm function in muscular dystrophy
Abstract Duchennemuscular dystrophy (DMD) is a severe, degenerativemuscle disease caused by dystrophin mutations. The mdx mouse is a widely used animal model of DMD. The mdx diaphragmmuscle most closely recapitulates key features ofDMDmuscles, including …
Publication
Myocardial Infarction Promoted the Contrast-Induced Nephropathy by Renal Injury
Abstract Background: The morbidity of myocardial infarction is keeping raise in this decade. Because of high safety and operability , percutaneous coronary intervention(PCI) has been used to conquer this disease for more than 20 years.An important …
Publication
A Selective TGFβ Ligand Trap Attenuates Pulmonary Hypertension.
RATIONALE Transforming Growth Factor-β (TGFβ) ligands signal via type I and type II serine-threonine kinase receptors to regulate broad transcriptional programs. Excessive TGFβ-mediated signaling is implicated in the pathogenesis of pulmonary arterial …
Publication
Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42
PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. This study was aimed at evaluating the efficacy of AR-42 (formerly OSU-HDAC42), a novel histone deacetylase (HDAC) inhibitor currently in …