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Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure
Fever is a highly conserved systemic response to infection dating back over 600 million years. Although conferring a survival benefit, fever can negatively impact the function of excitable tissues, such as the heart, producing cardiac arrhythmias. Here we …
Publication
PGC-1α1 induces cardiac excitation-contraction coupling phenotype without metabolic remodelling
The transcriptional coactivator PGC-1α1 has been identified as a central factor mediating metabolic adaptations of the heart. However, it is still mostly unresolved how much physiological changes in PGC-1α1 expression levels actually contribute to the …
Publication
Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy
We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant …
Publication
in a Rat Model
Hepatic infarcts or abscesses occur after hepatic artery interruption. We explored the mechanisms of hepatic deprivation–induced acute liver injury and determine whether partial portal vein arterialization attenuated this injury in rats. Male …
Publication
Comprehensive Echocardiographic Assessment of the Right Ventricle in Murine Models
Background: Non-invasive high-resolution echocardiography to evaluate cardiovascular function of small animals is increas- ingly being used due to availability of genetically engineered murine models. Even though guidelines and standard values for hu- …
Publication
Amelioration of cardiac dysfunction and ventricular remodeling after myocardial infarction by danhong injection are critically contributed by anti-TGF-β-mediated fibrosis and angiogenesis mechanisms
AB STR A CT Ethnopharmacological relevance: Danhong injection (DHI) is a standardized product extracted from Radix et Rhizoma Salviae Miltiorrhizae and Flos Carthami , which has been long applied mainly used to treat ischemic encephalopathy and cardiac …
Publication
Cardiovascular health effects of oral and pulmonary exposure to multi-walled carbon nanotubes in ApoE-deficient mice
Exposure to high aspect ratio nanomaterials, such as multi-walled carbon nanotubes (MWCNTs) may be associated with increased risk of atherosclerosis, pulmonary disease, and cancer. In the present study, we investigated the cardiovascular and pulmonary …
Publication
Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release
Background: Junctophilin-2 (JPH2) is the primary structural protein for the coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 ryanodine receptors on the sarcoplasmic reticulum within junctional membrane complexes (JMCs) in …
Publication
Adipocyte-specific loss of PPARγ attenuates cardiac hypertrophy
Adipose tissue is a key endocrine organ that governs systemic homeostasis. PPARγ is a master regulator of adipose tissue signaling that plays an essential role in insulin sensitivity, making it an important therapeutic target. The selective PPARγ agonist …
Publication
Innate Effector-Memory T Cell Activation Regulates Post-Thrombotic Vein Wall Inflammation and Thrombus Resolution
Rationale: Immune cells play an important role during the generation and resolution of thrombosis. T cells are powerful regulators of immune and non-immune cell function, however their role in sterile inflammation in venous thrombosis has not been …