Aortic stenosis, a common valvular heart disease, can lead to left ventricular pressure overload, triggering pro-fibrotic responses in the heart. miR-210 is a microRNA that responds to hypoxia and ischemia and plays a role in immune regulation and in …

Ultrasound-targeted nanobubble destruction (UTND) is a promising noninvasive strategy for cancer treatment. However, off-target effects significantly influence UTND-mediated therapeutic efficacy and compromise accurate evaluation of tumors. …

Background/Objective: Activity of SGK-1 has been associated with mechanical aspects of vascular remodeling and matrix stiffening has been a known characteristic of AAA. We hypothesis that VSMC-specific SGK-1 activity is vital to growth of AAA and …

Monitoring collagen may help physicians assess female reproductive health, since altered collagen with age is an established risk factor for female reproductive disorders including pelvic organ prolapse. Currently, quantifying collagen in soft tissues …

Cardiotoxicity is a potential side effect of doxorubicin (DOX). However, there is a lack of effective methods for the timely detection and precise treatment of DOX-induced cardiotoxicity (DIC). Here, snRNA-seq of the hearts of patients with DIC and bulk …

Introduction/Aims: Transthyretin amyloidosis (ATTR), including hereditary (hATTR) and wild-type (wtATTR), often presents initially as carpal tunnel syndrome (CTS), often preceding systemic symptoms by several years. Ultra high-resolution ultrasound …