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Tomographic ultrasound for three-dimensional visualization of temporal arteries
Objective: Conventional two-dimensional ultrasound has been assessed for the non-invasive diagnosis of giant cell arteritis (GCA), but the results are operator dependent, resulting in low sensitivity. Tomographic three-dimensional (3D) ultrasound is a …
Publication
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung
The mitochondrial adaptor protein p66Shc has been suggested to control life span in mice via the release of hydrogen peroxide. However, the role of p66Shc in lung aging remains unsolved. Thus, we investigated the effects of p66Shc-/- on the aging of the …
Publication
Anatomical evaluation of gingival tissues using ultra-high-frequency ultrasound: a preliminary study
Ultra-high-frequency ultrasound is a promising non-invasive imaging modality for evaluating superficial soft tissues. Its application in oral diagnostics is still emerging. This preliminary study aimed to assess the feasibility and anatomical resolution …
Publication
Ultrasound enhanced siRNA delivery using cationic liposome-microbubble complexes for the treatment of squamous cell carcinoma
Rationale: Microbubble (MB) contrast agents combined with ultrasound targeted microbubble cavitation (UTMC) are a promising platform for site-specific therapeutic oligonucleotide delivery. We investigated UTMC-mediated delivery of siRNA directed against …
Publication
Development of a Small-Footprint 50 MHz Linear Array: Fabrication and Micro-Ultrasound Imaging Demonstration
Compact high-frequency arrays are of interest for clinical and preclinical applications in which a small-footprint or endoscopic device is needed to reach the target anatomy. However, the fabrication of compact arrays entails the connection of several …
Publication
Nanoscale engineering of gold nanostars for enhanced photoacoustic imaging
Photoacoustic (PA) imaging is a diagnostic modality that combines the high contrast resolution of optical imaging with the high tissue penetration of ultrasound. While certain endogenous chromophores can be visualized via PA imaging, many diagnostic …
Publication
Nitric oxide nano-reactor DNMF/PLGA enables tumor vascular microenvironment and chemo-hyperthermia synergetic therapy
Background: Breast cancer ranks first among malignant tumors, of which triple-negative breast cancer (TNBC) is characterized by its highly invasive behavior and the worst prognosis. Timely diagnosis and precise treatment of TNBC are substantially …
Publication
Gestational exposure to micro and nanoplastics differentially impactscardiac development and function in male and female rats throughout the lifespan
Gestational exposure to micro and nanoplastics differentially impactscardiac development and function in male and female rats throughout the …
Publication
Establishment of a hybrid model of atherosclerosis and acute colitis in ApoE-/mice
Inflammatory bowel disease (IBD) and atherosclerosis (AS) are both common chronic inflammatory diseases with similar pathophysiological mechanisms. Some studies have shown that IBD patients are at increased risk for early atherosclerosis, myocardial …
Publication
A “defend–attack and capture flag” strategy for cascade management of hepatic ischemia reperfusion injury
Hepatic ischemia reperfusion injury (HIRI) following transplantation or resection can lead to irreversible liver dysfunction and even failure, yet current therapeutic interventions are limited. Herein, we introduce a “defend–attack and capture flag” …