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Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice
Aortic aneurysm is characterized by a pathological dilation at specific predilection sites of the vessel and potentially results in life-threatening vascular rupture. Herein, we established a modified “Häutchen method” for the local isolation of …
Publication
Impaired memory in Sprague-Dawley rats exposed to complex groundwater mixtures of contaminants is associated with reduced cranial blood flow and hippocampal neurotoxicity
Exposure to industrial contaminants has been implicated in neurobehavioral toxicity in humans. To explore this potential risk, we investigated the neurotoxic effects of oral exposure to a complex groundwater mixture containing petroleum hydrocarbons, …
Publication
Toward Smart Ultrasound Image Augmentation to Advance Tumor Treatment Monitoring: Exploring the Potential of Diffusion Generative Model
Medical imaging is a crucial tool in clinics to monitor tumor treatment progress. In practice, many imaging tools (such as magnetic resonance imaging (MRI) and computed tomography (CT) scans) are in general costly and may also expose patients to …
Publication
Targeted opening of the blood-brain barrier using VCAM-1 functionalised microbubbles and “whole brain” ultrasound
Metastatic tumours in the brain now represent one of the leading causes of death from cancer. Current treatments are largely ineffective owing to the combination of late diagnosis and poor delivery of therapies across the blood-brain barrier (BBB). …
Publication
Toll-like receptor 4 mutation mitigates gut microbiota-mediated hypertensive kidney injury
Hypertension-associated dysbiosis is linked to several clinical complications, including inflammation and possible kidney dysfunction. Inflammation and TLR4 activation during hypertension result from gut dysbiosis-related impairment of intestinal …
Publication
Identification and characterization of TM4SF1+ tumor self-seeded cells
Tumor self-seeding is a process whereby circulating tumor cells (CTCs) recolonize the primary tumor, which promotes tumor growth, angiogenesis, and invasion. However, the detailed nature and functions of tumor self-seeded cells (TSCs) have not been well …
Publication
Macrophage-Targeted multifunctional nanoparticles for detection and treatment of intraplaque hemorrhage
Intraplaque hemorrhage (IPH) is a critical contributor to atherosclerotic plaque progression and destabilization; however, its timely detection and treatment of IPH are limited. In this study, novel macrophage-targeted nanoparticles (NPs) are developed …
Publication
Macrophage membrane-reversibly camouflaged nanotherapeutics accelerate fracture healing by fostering MSCs recruitment and osteogenic differentiation
The fracture healing outcome is largely dependent on the quantities as well as osteogenic differentiation capacities of mesenchymal stem cells (MSCs) at the lesion site. Herein, macrophage membrane (MM)-reversibly cloaked nanocomplexes (NCs) are …
Publication
Advanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters
Background: Advanced glycation end product-modified low-density lipoprotein (AGE-LDL) is related to inflammation and the development of atherosclerosis. Additionally, it has been demonstrated that receptor for advanced glycation end products (RAGE) has a …
Publication
A highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model
Abdominal aortic aneurysm (AAA) is a deadly, permanent ballooning of the aortic artery. Pharmacological and genetic studies have pointed to multiple proteins, including microsomal prostaglandin E2 synthase-1 (mPGES-1), as potentially promising targets. …