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Echocardiographic Assessment of Pulmonary Hemodynamics and Right Ventricular Performance in Neonatal Murine Hypoxia
Background: Right heart catheterization (RHC) is the gold-standard for diagnosis of pulmonary hypertension (PH) but is a terminal procedure in neonatal mice. The objective was to validate echocardiographic measures of PH to establish the diagnostic …
Publication
Comparative analysis of ALA mediated sonodynamic therapy considering tumor size, light combination and ultrasound delivery in murine cutaneous melanoma
Sonodynamic therapy (SDT) is a non-invasive alternative treatment for cancer. However, its effects on early-stage and intradermally implanted melanoma remain underexplored. Here, we investigated the in vivo effects of 5-aminolevulinic acid (ALA)-mediated …
Publication
Biosynthetic gas vesicles as a novel ultrasound contrast agent for diagnosing and treating myocardial infarction
Biosynthetic gas vesicles as a novel ultrasound contrast agent for diagnosing and treating myocardial infarction …
Publication
Targeting STING to disrupt macrophage-mediated adhesion in encapsulating peritoneal sclerosis
Encapsulating peritoneal sclerosis (EPS) is a life-threatening fibrotic condition characterized by severe abdominal adhesions, chronic inflammation, and significant morbidity. The lack of effective treatments for EPS stems from a limited understanding of …
Publication
Comparison of high-frequency ultrasound transducers for microvascular localization microscopy in the mouse brain
Ultrasound localization microscopy is a super-resolution vascular imaging technique which has garnered substantial interest as a tool for small animal neuroimaging, neuroscience research, and the characterization of vascular pathologies. In the context of …
Publication
Targeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle cells
Targeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle …
Publication
Cu2(OH)PO4@PAA Nanoparticles for Highly Effective Combination of Chemodynamic, Photodynamic and Photothermal Therapies Against Bladder Cancer
Background: Due to the complex structure and variable microenvironment in the progression of bladder cancer, the efficacy of traditional treatment methods such as surgery and chemotherapy is limited. Tumor residual, recurrence and metastasis are still …
Publication
Multiscale molecular engineering co-modulated dual-mode ratiometric probe for monitoring tumor-associated macrophage repolarization
Multiscale molecular engineering co-modulated dual-mode ratiometric probe for monitoring tumor-associated macrophage repolarization …
Publication
Carrier-free nanoparticles based on natural products trigger dual “synergy and attenuation” for enhanced phototherapy of liver cancer
Carrier-free nanoparticles have attracted significant interest owing to their exceptional drug-loading efficiency, simple preparation, and good biosafety. Inspired by the synergism and attenuation strategy of natural products, carrier-free nanoparticles …
Publication
Ultrasound-Guided Photoacoustic Monitoring of Vascular Ischemia in Implant-Induced Skin Necrosis
Ultrasound-Guided Photoacoustic Monitoring of Vascular Ischemia in Implant-Induced Skin Necrosis …