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Identification of congenital aortic valve malformations in juvenile natriuretic peptide receptor 2-deficient mice using high-frequency ultrasound
Mouse models of congenital aortic valve malformations are useful for studying disease pathobiology, but most models have incomplete penetrance [e.g., ~2 to 77% prevalence of bicuspid aortic valves (BAVs) across multiple models]. For longitudinal studies …
Publication
Glutamine Protects against Mouse Abdominal Aortic Aneurysm through Modulating VSMC Apoptosis and M1 Macrophage Activation
Glutamine (Gln), known as the most abundant free amino acid, is widely spread in human body. In this study, we demonstrated the protective effects of glutamine against mouse abdominal aortic aneurysm (AAA) induced by both angiotensin II (AngII) and …
Publication
Ganlu formula ethyl acetate extract (GLEE) blocked the development of experimental arthritis by inhibiting NLRP3 activation and reducing M1 type macrophage polarization
Ethnopharmacological relevance: The Tibetan medicine Ganlu Formula, as a classic prescription, is widely used across the Qinghai-Tibet Plateau area of China, which has a significant effect on relieving the course of rheumatoid arthritis (RA). However, the …
Publication
A SU6668 pure nanoparticle-based eyedrops: toward its high drug Accumulation and Long-time treatment for corneal neovascularization
Corneal neovascularization (CNV) is one of the common blinding factors worldwide, leading to reduced vision or even blindness. However, current treatments such as surgical intervention and anti-VEGF agent therapy still have some shortcomings or evoke some …
Publication
Thermoresponsive polymer encapsulated HT1080 exosomes lyse localized blood clot: A preclinical evaluation in rat carotid artery thrombosis model
Since tissue plasminogen activators have limitations, an alternate therapeutic agent is needed with similar clot lysis activity and better stability to degrade thrombus. We have identified HT1080 fibrosarcoma cell-derived exosomes having clot-busting …
Publication
Atrial Myopathy Quantified by Speckle-tracking Echocardiography in Mice
BACKGROUND: Emerging evidence suggests that atrial myopathy may be the underlying pathophysiology that explains adverse cardiovascular outcomes in heart failure (HF) and atrial fibrillation. Lower left atrial (LA) function (strain) is a key biomarker of …
Publication
Single pulmonary nanopolystyrene exposure in late-stage pregnancy dysregulates maternal and fetal cardiovascular function
Large-scale production and waste of plastic materials have resulted in widespread environmental contamination by the breakdown product of bulk plastic materials to micro- and nanoplastics (MNPs). The small size of these particles enables their suspension …
Publication
Super-Resolution Ultrasound Imaging for Monitoring the Therapeutic Efficacy of a Vascular Disrupting Agent in an Animal Model of Breast Cancer
Objective: Evaluate the use of super-resolution ultrasound (SRUS) imaging for the early detection of tumor response to treatment using a vascular-disrupting agent (VDA). Methods: A population of 28 female nude athymic mice (Charles River Laboratories) …
Publication
A central arteriovenous fistula reduces systemic hypertension in a mouse model
Objective: A central arteriovenous fistula (AVF) has been proposed as a potential novel solution to treat patients with refractory hypertension. We hypothesized that venous remodeling after AVF creation in the hypertensive environment reduces systemic …
Publication
IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia
Preeclampsia (PE), a leading cause of maternal/fetal morbidity and mortality, is a hypertensive pregnancy disorder with endorgan damage that manifests after 20 wk of gestation. PE is characterized by chronic immune activation and endothelial dysfunction. …