Efficient mitochondrial matrix protein quality control (mPQC), regulated by the mitochondrial matrix protease LONP1, is essential for preserving cardiac bioenergetics, particularly in post-mitotic cardiomyocytes, which are highly susceptible to …

Sox17 mediates venous adaptive remodeling after arteriovenous fistula creation …

Cancer Cell Membrane-Wrapped Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Triple-Negative Breast Cancer …

Background: Extracellular vesicles (EVs) derived from M2 macrophages (M2-EVs) play a protective role in the pathogenesis of acute lung injury. However, their roles and mechanisms in abdominal aortic aneurysm (AAA) are unknown. Methods: The effects of …

Age-associated atrial myopathy results in structural remodeling and a disturbance of atrial conductance. Atrial myopathy often precedes atrial fibrillation (AF) and can facilitate AF progression. However, the molecular mechanism linking aging to atrial …

Cross Amplitude Modulation and Compound Amplitude Modulation for Nonlinear Contrast-Enhanced Ultrasound Imaging of Nanobubbles …

The onset and progression of the inflammatory response and reaction are complex mechanisms dependent on the balance of activity between different and counteracting targets and enzymatic systems. The understanding and, even more importantly, the …

Optogenetics offers a minimally invasive, low-fatigue, and temporally precise alternative to electrical stimulation for skeletal muscle control. After opsin expression in muscle cells, contraction can be stimulated with light. Obstructive sleep apnea, …

Pathology in large vessels frequently develops at specific locations, implying that local stressors and spatially restricted gene expression are likely contributors to disease susceptibility. Here we perform single-cell transcriptomics in the carotids, …

Triple-negative breast cancer (TNBC) poses a serious threat to women's health. Currently, chemotherapy remains the first-line treatment in the clinic, and more comprehensive treatments are urgently needed to improve the therapeutic efficacy of TNBC. …