Computational models predicted that peripapillary sclera (PPS) stiffening may reduce intraocular pressure (IOP) induced stresses and strains at the optic nerve head (ONH). Experimental studies in animal models of glaucoma however did not confirm such …

This study presents an examination of whether the double overexpression of ZNF746 and cellular prion protein (PrPC) genes in rat adipose-derived mesenchymal stromal cells (ADMSCs) (ie, MSCDGe-OVE) offered enhanced protection to the livers of rats against …

Nelumbinis Plumula Attenuates High-Fat-induced Inflammation in Non-Alcoholic Fatty Liver Through The NOX/NF-κB Pathway …

In clinical applications of super-resolution ultrasound imaging, it is often not possible to achieve a full reconstruction of the microvasculature within a limited measurement time. This makes the comparison of studies and quantitative parameters of …

Objectives: Sirtuin 6 (SIRT6) is a longevity-associated gene with recognized therapeutic potential for vascular aging through the regulation of vascular smooth muscle cells (VSMCs) senescence. This study aims to develop a visualized nanodelivery system …

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and while five-year survival rates exceed 90 %, survivors display neurocognitive deficits. Magnetic resonance imaging (MRI) measurements indicate smaller volume across the brain in …

Objectives.Arteriovenous fistula (AVF) failure is a frequent clinical problem among end stage renal patients seeking durable long term dialysis access. The most common histologicalin vivoobservation of AVF failure is endothelial injury at the …

The tumor-stroma interaction contributes to the aggressive and resistance nature of pancreatic ductal adenocarcinoma (PDAC), leading to treatment failure. Cancer-associated fibroblasts (CAFs), a key cell type in the stroma, produce abundant extracellular …

Antidepressant use during pregnancy is increasingly common, with selective serotonin reuptake inhibitors (SSRIs) widely prescribed for maternal depression. However, growing evidence links prenatal SSRI exposure to adverse outcomes, including impaired …

Abdominal aortic aneurysm (AAA) and the attendant catastrophic event of rupture remain a leading cause of death. Germline mutation of RRAS2 cause Noonan Syndrome, yet little is known about its function in AAA pathogenesis. Integrated analysis of RNA-seq …