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ALDOB K87 lactylation drives mitochondrial fission and metabolic reprogramming in pulmonary hypertension
ALDOB K87 lactylation drives mitochondrial fission and metabolic reprogramming in pulmonary hypertension …
Publication
Cross-species single-cell transcriptomic analysis unveils conserved myeloid signatures in abdominal aortic aneurysm: implications for therapeutic targeting
Cross-species single-cell transcriptomic analysis unveils conserved myeloid signatures in abdominal aortic aneurysm: implications for therapeutic …
Publication
A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome
A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome …
Publication
Seeing More to Treat Better: Ultra-High Frequency Ultrasound as a Decision-Shaping Tool in Radiotherapy for Head and Neck Non-Melanoma Skin Cancer in a Single-Institution Feasibility Study
Background/Objectives: Accurate target delineation is critical in radiotherapy for head and neck non-melanoma skin cancer (NMSC), where tumor depth and subclinical extension are often underestimated by clinical and dermoscopic assessment alone. While high …
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Implantable Microdevices for In Vivo Assessment of Chemotherapy Response in Patient Derived Organoid Orthotopic Pancreatic Cancer Models
Implantable Microdevices for In Vivo Assessment of Chemotherapy Response in Patient Derived Organoid Orthotopic Pancreatic Cancer …
Publication
Cardiovascular Effects of Early and Postponed Statin Treatment After Ovariectomy in Prediabetic Rat
We investigated the effects of early and postponed statin therapy after ovariectomy on the cardiovascular system in an experimental model of insulin resistance (hereditary hypertriglyceridemic rats). Thirty hereditary hypertriglyceridemic rats were …
Publication
Acoustic delivery of indocyanine green via biosynthetic gas vesicles for tumor photothermal therapy
Photothermal therapy (PTT) serves as a complementary strategy to conventional cancer treatments. Indocyanine green (ICG) is the only U.S. Food and Drug Administration (FDA)-approved photothermal agent. However, its clinical application is hindered by poor …
Publication
Parental obesity exacerbates cognitive dysfunction and cardiac vulnerability in offspring of an Alzheimer disease model
Parental obesity is associated with worsened cognitive performance and male-specific impairments in cardiac metabolism and function in AD-susceptible offspring, highlighting developmental programming as a modifier of heart-brain …
Publication
Efficient algorithm for optimal wavelength selection in photoacoustic spectral unmixing
We present a method for numerically determining the optimal wavelengths to perform spectral unmixing in photoacoustic experiments. The proposed method employs a rugged-landscape-model-inspired stochastic hill-climbing approach that can reliably and …
Publication
Lipoic acid-engineered nanodroplets for multimodal imaging and enhanced sonodynamic therapy in melanoma treatment
Lipoic acid-engineered nanodroplets for multimodal imaging and enhanced sonodynamic therapy in melanoma treatment …