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Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice
Imbalance of proinflammatory and anti-inflammatory responses plays a crucial role in the progression of abdominal aortic aneurysms. ILF3, a known modulator of the innate immune response, is involved in cardiovascular diseases. This study aims to …
Publication
Fluorescence and photoacoustic (FL/PA) dual-modal probe: Responsive to reactive oxygen species (ROS) for atherosclerotic plaque imaging
Accurate and early detection of atherosclerosis (AS) is imperative for their effective treatment. However, fluorescence probes for efficient diagnosis of AS often encounter insufficient deep tissue penetration, which hinders the reliable assessment of …
Publication
The paravertebral lymphatic system is involved in the resorption of the herniated nucleus pulposus and the regression of inflammation associated with disc herniation
Objective: To investigate the role of the paravertebral lymphatic system in the nucleus pulposus herniation (NPH) resorption and the inflammation regression. Design: Clinical specimens (n = 10) from patients with lumbar disc herniation (LDH) were …
Publication
RNA nanotherapeutics with fibrosis overexpression and retention for MASH treatment
Metabolic dysfunction-associated steatohepatitis (MASH) poses challenges for targeted delivery and retention of therapeutic proteins due to excess extracellular matrix (ECM). Here we present a new approach to treat MASH, termed “Fibrosis overexpression …
Publication
SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal (CR) protection in CR syndrome rodent fed with high protein diet
This study tested the hypothesis that empagliflozin (EMPA) therapy effectively protected renal and heart functions via downregulating reactive oxygen species (ROS) and activating AMPK signaling in cardiorenal syndrome (CRS) (induced by doxorubicin-5/6 …
Publication
Impact of bradykinin type 2 receptor overexpression on cardiovascular function in mice
Bradykinin is an endogenous peptide playing an important role in regulation of vascular function and permeability, but cardiovascular effects of endogenous bradykinin remain incompletely understood. We studied whether genetically engineered overexpression …
Publication
Photoacoustic features of nylon-11 nanoparticles for breast cancer imaging, and their modification with trastuzumab, sorafenib, and nutlin-3a for theranostic applications
Breast cancer is a complex and diverse disease that requires accurate diagnostic methods and customized treatment approaches to enhance patient outcomes. In this study, we investigate the potential of nylon-11 nanoparticles (nylon NPs) for both imaging …
Publication
Scaffold-Forming Collagen and Motor-Endplate Expressing Muscle Cells for Porcine Laryngoplasty
Objective: Vocal fold paralysis impairs quality of life, and no curative injectable therapy exists. We evaluated injection of a novel in situ polymerizing (scaffold-forming) collagen in the presence and absence of muscle-derived motor-endplate expressing …
Publication
Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice
The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 participants were recruited for the screening of differentially expressed plasma microRNAs (miRNAs). We found that miR-1204 is significantly …
Publication
Gestational exposure to air pollutants perturbs metabolic and placenta-fetal phenotype
Air pollution (AP) is detrimental to pregnancies including increasing risk factors of gestational diabetes mellitus. We hypothesized that exposure to AP causes cardiovascular and metabolic disruption thereby altering placental gene expression, which in …