Liver fibrosis (LF) afflicts millions of patients worldwide, yet a universally accepted standard therapy remains elusive. Notably, an elevation of profibrotic monocytes is observed in peripheral blood of LF patients. Inspired by the spleen's reported …

The transcriptional response to hypoxia is temporally regulated, yet the molecular underpinnings and physiological implications are unknown. We examined the roles of hepatic Bmal1 and Hif1α in the circadian response to hypoxia in mice. We found that the …

Establishment of a Modified Ferric Chloride-Induced Canine Superficial Femoral Artery Thrombosis Model …

Abdominal aortic aneurysm (AAA) is a life‐threatening vascular disorder lacking effective pharmacological interventions. We identified CD5 molecule‐like (CD5L) as a regulator of macrophage polarization in AAA via the phosphoinositide 3‐kinase/protein …

Naphthalocyanines are emerging as highly promising photosensitizers, owing to their intensive absorption ( ε > 1 × 10 5 M −1 cm −1 ) beyond 800 nm, but their poor solubility in biological media has significantly limited their clinical translation. In this …

This study evaluated the effectiveness of non-invasive ultrasound technology in monitoring pulmonary edema in a mouse model of acute lung injury (ALI). Male C57BL/6J mice were instilled through the trachea with lipopolysaccharide (LPS, 5 mg/kg, single …

Heat shock factor 1 (HSF1) is a key stress-protective transcription factor that acts as a guardian of proteostasis. HSF1 also plays multifaceted roles in tumor-associated processes including proliferation and metastasis. HSF1 is frequently overexpressed …

The Regulatory Effects of Low-Intensity Pulsed Ultrasound Combined With Stretching on Muscle Tension Relief: Focusing on the Microstructural …

BACKGROUND: Ferroptosis therapy has emerged as a promising antitumor strategy by utilizing the Fenton reaction to destroy cancer cells, where Fe2+ catalyzes the decomposition of H2O2 into hydroxyl radicals (•OH). Despite the great potential of ferroptosis …

Computational models predicted that peripapillary sclera (PPS) stiffening may reduce intraocular pressure (IOP) induced stresses and strains at the optic nerve head (ONH). Experimental studies in animal models of glaucoma however did not confirm such …