Search
Publication
Mutation of the calmodulin binding motif IQ of the L-type Ca(v)1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death.
Cardiac excitation-contraction coupling (EC coupling) links the electrical excitation of the cell membrane to the mechanical contractile machinery of the heart. Calcium channels are major players of EC coupling and are regulated by voltage and …
Publication
Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.
RATIONALE: The myeloid differentiation factor (MyD)88/interleukin (IL)-1 axis activates self-antigen-presenting cells and promotes autoreactive CD4(+) T-cell expansion in experimental autoimmune myocarditis, a mouse model of inflammatory heart disease. …
Publication
Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene.
AIMS: Mutations in A-type nuclear lamins gene, LMNA, lead to a dilated cardiomyopathy. We have reported abnormal activation of the extracellular signal-regulated kinase1/2 (ERK1/2) signalling in hearts from Lmna(H222P/H222P) mice, which develop dilated …
Publication
Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.
BACKGROUND: Ischemic cardiomyopathy is the major cause of heart failure and a significant cause of morbidity and mortality. The degree of left ventricular dysfunction in this setting is often out of proportion to the amount of overtly infarcted tissue, …
Resource
Translational Research: Non-invasive Morphological and Functional Assessment of Biological Structures
A conversation with Dr. Francesca IACOBELLIS: a specialist radiologist at Centre of Biotechnology of “A. Cardarelli” Hospital, Naples, explained how Ultra high frequency ultrasound imaging is enabling non-invasive morphological and functional assessment …
Resource
Imaging Zebrafish with High Frequency Ultrasound
Zebrafish are model organisms for biomedical research. There are structural, functional, and genetic similarities with humans that make zebrafish a useful model for not only cardiovascular research but also oncology, developmental biology and aquaculture. …
Resource
February 2019: Assessment of Myocardial Dynamics using Photoacoustics & Cardiac Elastography: In-vivo Results in Murine Ischemia
Presenter: Rashid Al-Mukaddim, Graduate Research Assistant – Medical Physics at the University of Wisconsin. In this webinar: Principles of Photoacoustic (PA) Imaging, and its application in cardiovascular research Results from in vivo studies of …
Page
Vevo Travel Award 2019 Recipients
ONCOLOGY TRACK: Dr. Fatima Ryalat from Wake Forest University, USA Title: Muscadine Grape Extract Treatment Improves Aortic Pulse Wave Velocity and Superior Mesenteric Artery Pulsatility Index in Hypertensive Transgenic (mRen2)27 Female Rats Presenting …