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Lmo4 Establishes Rostral Motor Cortex Projection Neuron Subtype Diversity
The mammalian neocortex is parcellated into anatomically and functionally distinct areas. The establishment of area-specific neuronal diversity and circuit connectivity enables distinct neocortical regions to control diverse and specialized functional …
Publication
Functional Imaging of the Rat Brain with Micro-Ultrasound
Functional Imaging of the Rat Brain with Micro-Ultrasound …
Publication
Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization
Currently, there is no adequate technology to detect early stage ovarian cancers. Most of the cancers in the ovary are detected when the cancer has already metastasized to other parts of the body. As a result, ovarian cancer has the highest mortality of …
Publication
Doppler flow velocity waveforms in the embryonic chicken heart at developmental stages corresponding to 5-8 weeks of human gestation.
OBJECTIVES: To obtain Doppler velocity waveforms from the early embryonic chicken heart by means of ultrasound biomicroscopy and to compare these waveforms at different stages of embryonic development. METHODS: We collected cardiac waveforms using …
Publication
Developmental changes in left and right ventricular diastolic filling patterns in mice
Developmental changes in left and right ventricular diastolic filling patterns were determined non-invasively in isoflurane-anesthetized outbred ICR mice. Blood velocities in the mitral and tricuspid orifices were recorded in 16 embryos at day 14.5 …
Publication
High-frequency ultrasound assessment of the murine heart from embryo through to juvenile.
AIM: The aim of this study is to assess the murine heart of normal embryos, neonates, and juveniles using high-frequency ultrasound. METHODS: Diastolic function was measured with E/A ratio (E wave velocity/A wave velocity) and isovolumetric relaxation …
Publication
Initial experience with high frequency ultrasound for the newborn C57BL mouse.
The mouse has become a powerful genetic tool for studying genes involved in cardiac development and congenital heart disease. Many of the most severe congenital heart defects are ductal-dependent, resulting in neonatal lethality. Recent advances in …
Publication
Recapitulation of developmental cardiogenesis governs the morphological and functional regeneration of adult newt hearts following injury.
Urodele amphibians, like the newt, are the "champions of regeneration" as they are able to regenerate many body parts and tissues. Previous experiments, however, have suggested that the newt heart has only a limited regeneration capacity, similar to the …
Publication
Heart of newt: a recipe for regeneration.
The field of regenerative medicine holds tremendous promise for the treatment of chronic diseases. While the adult mammalian heart has limited regenerative capacity, previous studies have focused on cellular therapeutic strategies in an attempt to …
Publication
Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish
Systemic amyloid light-chain (AL) amyloidosis is associated with rapidly progressive and fatal cardiomyopathy resulting from the direct cardiotoxic effects of circulating AL light chain (AL-LC) proteins and the indirect effects of AL fibril tissue …