Cellular proliferation is a basic process during organ development, tissue homeostasis and disease progression. Likewise, after injury typically multiple cell lineages respond to various cues and proliferate to initiate repair and/or remodeling of the …

Purpose: In vivo evaluation of corneal biomechanics holds the potential for improving diagnosis and management of ocular diseases. We aimed to develop an ocular pulse elastography (OPE) technique to quantify corneal strains generated by naturally …

Cardiac fibrosis is associated with fine particulate matter (PM2.5) exposure. In addition, whether high-fat diet (HFD) could exacerbate the PM2.5-induced cardiac injury was unevaluated. Thus, this study was aimed to investigate the combined effects of …

Although it is possible for inhalation of ultrafine particles to impair human health, its effect is not clear in patients with HFpEF. This study investigated cardiac and hemodynamic changes in hypertension-induced rats of HFpEF after inhaling ultrafine …

Biomimetic synthesis is a promising strategy for the preparation of nanotheranostics with excellent biocompatibility. Herein, we report a biomimetic approach to synthesize folic acid (FA) modified copper sulfide (CuS) nanodots for cancer phototheranostics …

Despite proven efficacy of pharmacotherapies targeting primarily global neurohormonal dysregulation, heart failure (HF) is a growing pandemic with increasing burden. Treatments mechanistically focusing at the cardiomyocyte level are lacking. MicroRNAs …

Nanocarriers for chemo-photothermal therapy suffer from insufficient retention at the tumor site and poor penetration into tumor parenchyma. A smart drug-dye-based micelle is designed by making the best of the structural features of small-molecule drugs. …

Aims: The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here …

The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis, homeostasis and function. Vascular endothelial growth factor-a (VEGFA) has been commonly recognized as a pro-angiogenic factor in vertebrate developmental, …

Heart disease is the leading cause of death in the western world. Attaining a mechanistic understanding of human heart development and homeostasis and the molecular basis of associated disease states relies on the use of animal models. Here, we present …