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Non-invasive real-time imaging of atherosclerosis in mice using ultrasound biomicroscopy.
There are increasing needs to develop imaging techniques to study in vivo vascular morphology and function in various mouse models of atherosclerosis. Using ultrasound biomicroscopy (UBM), we developed and validated a new imaging protocol to follow lesion …
Publication
Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis.
Atherosclerosis is closely associated with disturbed flow characterized by low and oscillatory shear stress, but studies directly linking disturbed flow to atherogenesis is lacking. The major reason for this has been a lack of an animal model in which …
Publication
Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus
Copy number variation (CNV) has been associated increasingly with altered susceptibility to human disease. Large CNVs are likely to incur disease risk or resilience via predictable changes in gene dosage that are relatively straightforward to model using …
Publication
Photoacoustic imaging of the bladder: a pilot study.
Photoacoustic imaging is a promising new technology that combines tissue optical characteristics with ultrasound transmission and can potentially visualize tumor depth in bladder cancer. We imaged simulated tumors in 5 fresh porcine bladders with …
Publication
Gene Inactivation of Proprotein Convertase Subtilisin/Kexin Type 9 Reduces Atherosclerosis in Mice
BACKGROUND: The proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes independently of its enzymatic activity the degradation of the low-density lipoprotein (LDL) receptor. PCSK9 gain of function in humans leads to autosomal dominant …
Publication
Micro-Ultrasonographic Imaging of Atherosclerotic Progression
We studied prospectively whether atherosclerotic progression in apolipoprotein-E knock- out mice could be noninvasively and accurately measured by use of high-resolution ultra- sonographic biomicroscopy. We examined the correlation between the …
Publication
Micro-ultrasound imaging assessment of carotid plaque characteristics in apolipoprotein-E knockout mice.
This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and …
Publication
A Critical Function of Th17 Proinflammatory Cells in the Development of Atherosclerotic Plaque in Mice
Considerable evidence supports that the CD4(+) T cell-mediated immune response contributes to the development of atherosclerotic plaque. However, the effects of Th17 cells on atherosclerosis are not thoroughly understood. In this study, we evaluated the …
Publication
Aortic regurgitation dramatically alters the distribution of atherosclerotic lesions and enhances atherogenesis in mice.
OBJECTIVE: Hemodynamics plays a critical role in atherogenesis, but the association between flow pattern and preferential localization of lesion is not fully understood. We developed a mouse model of aortic valve regurgitation (AR) to change the aortic …
Publication
Cardiac angiogenic imbalance leads to peripartum cardiomyopathy
Peripartum cardiomyopathy (PPCM) is an often fatal disease that affects pregnant women who are near delivery, and it occurs more frequently in women with pre-eclampsia and/or multiple gestation. The aetiology of PPCM, and why it is associated with …