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A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma.
Most anticancer drugs entering clinical trials fail to achieve approval from the U.S. Food and Drug Administration. Drug development is hampered by the lack of preclinical models with therapeutic predictive value. Herein, we report the development and …
Publication
Kidney Development
Ultrasound (US) is the most common and least invasive modality for clinical imaging of the kidney. One important application of US in nephrology is the detection and monitoring of structural changes in the kidney. Recent advances in US technology have …
Publication
Matrix metalloproteinase inhibition mitigates renovascular remodeling in salt-sensitive hypertension
Extracellular matrix (ECM) remodeling is the hallmark of hypertensive nephropathy. Uncontrolled proteolytic activity due to an imbalance between matrix metalloproteinases and tissue inhibitors of metalloproteinases (MMPs/ TIMPs) has been implicated in …
Publication
Investigation and identification of etiologies involved in the development of acquired hydronephrosis in aged laboratory mice with the use of high-frequency ultrasound imaging
Laboratory mice develop naturally occurring lesions that affect biomedical research. Hydronephrosis is a recognized pathologic abnormality of the mouse kidney. Acquired hydronephrosis can affect any mouse, as it is caused by any naturally occurring …
Publication
Renal Retention of Lipid Microbubbles: A Potential Mechanism for Flank Discomfort During Ultrasound Contrast Administration
BACKGROUND: The etiology of flank pain sometimes experienced during the administration of ultrasound contrast agents is unknown. The aim of this study was to investigate whether microbubble ultrasound contrast agents are retained within the renal …
Publication
Molecular Imaging of Vascular Endothelial Growth Factor Receptor 2 Expression using targeted contrast enhanced High frequency ultrasonography
The aim of our study was to investigate the use of targeted con- trast-enhanced high-frequency ultrasonography for molecular imaging of vascular endothelial growth factor receptor 2 (VEGFR2) expression on tumor vascular endothelium in murine models of …
Publication
Ultrasound molecular imaging of secreted frizzled related protein-2 expression in murine angiosarcoma.
Angiosarcoma is a biologically aggressive vascular malignancy with a high metastatic potential. In the era of targeted medicine, knowledge of specific molecular tumor characteristics has become more important. Molecular imaging using targeted ultrasound …
Publication
Lmo4 and Clim1 Progressively Delineate Cortical Projection Neuron Subtypes during Development
Molecular controls over the development of the exceptional neuronal subtype diversity of the cerebral cortex are now beginning to be identified. The initial subtype fate decision early in the life of a neuron, and the malleability of this fate when the …
Publication
Origin and Molecular Specification of Globus Pallidus Neurons
The mechanisms controlling the assembly of brain nuclei are poorly understood. In the forebrain, it is typically assumed that the formation of nuclei follows a similar sequence of events that in the cortex. In this structure, projection neurons are …
Publication
Area-specific temporal control of corticospinal motor neuron differentiation by COUP-TFI
Transcription factors with gradients of expression in neocortical progenitors give rise to distinct motor and sensory cortical areas by controlling the area-specific differentiation of distinct neuronal subtypes. However, the molecular mechanisms …