The functional consequences of the familial hypertrophic cardiomyopathy A57G (alanine-to-glycine) mutation in the myosin ventricular essential light chain (ELC) were assessed in vitro and in vivo using previously generated transgenic (Tg) mice expressing …

Oxidative stress plays an important role in cardiac diseases, which has been well demonstrated, whereas the role of reductive stress has been poorly investigated. We and others have shown previously that heat shock protein 27 (Hsp27) plays a role as an …

Cardiac excitation-contraction coupling (EC coupling) links the electrical excitation of the cell membrane to the mechanical contractile machinery of the heart. Calcium channels are major players of EC coupling and are regulated by voltage and …

RATIONALE: The myeloid differentiation factor (MyD)88/interleukin (IL)-1 axis activates self-antigen-presenting cells and promotes autoreactive CD4(+) T-cell expansion in experimental autoimmune myocarditis, a mouse model of inflammatory heart disease. …

AIMS: Mutations in A-type nuclear lamins gene, LMNA, lead to a dilated cardiomyopathy. We have reported abnormal activation of the extracellular signal-regulated kinase1/2 (ERK1/2) signalling in hearts from Lmna(H222P/H222P) mice, which develop dilated …

BACKGROUND: Ischemic cardiomyopathy is the major cause of heart failure and a significant cause of morbidity and mortality. The degree of left ventricular dysfunction in this setting is often out of proportion to the amount of overtly infarcted tissue, …

A conversation with Dr. Francesca IACOBELLIS: a specialist radiologist at Centre of Biotechnology of “A. Cardarelli” Hospital, Naples, explained how Ultra high frequency ultrasound imaging is enabling non-invasive morphological and functional assessment …

Zebrafish are model organisms for biomedical research. There are structural, functional, and genetic similarities with humans that make zebrafish a useful model for not only cardiovascular research but also oncology, developmental biology and aquaculture. …

Presenter: Rashid Al-Mukaddim, Graduate Research Assistant – Medical Physics at the University of Wisconsin.  In this webinar: Principles of Photoacoustic (PA) Imaging, and its application in cardiovascular research Results from in vivo studies of …