Search
Publication
LncRNA MALAT1 protects cardiomyocytes from isoproterenol‐induced apoptosis through sponging miR‐558 to enhance ULK1‐mediated protective autophagy
Investigating the molecular mechanisms of myocardial infarction (MI) and subsequent heart failure have gained considerable attention worldwide. Long noncoding RNA (lncRNA) metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) has been previously …
Publication
In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources
Preclinical noninvasive imaging can be an indispensable tool for studying animal models of disease. In vivo imaging to assess anatomical, functional, and molecular features requires verification by a comparison to the macroscopic and microscopic …
Publication
A Specific Circulating MicroRNA Cluster Is Associated to Late Differential Cardiac Response to Doxorubicin-Induced Cardiotoxicity In Vivo
Background . Cardiotoxicity is a detrimental side effect of the anticancer drug doxorubicin (DOX), characterized by progressive heart dysfunction. Circulating microRNAs (miRNAs) are recognized as potential biomarkers of cardiac disease; thus, we aimed to …
Publication
Fibroblast Growth Factor 21 Attenuates Vascular Calcification by Alleviating Endoplasmic Reticulum Stress Mediated Apoptosis in Rats
Fibroblast growth factor 21 (FGF21), a hormone with multiple metabolic properties, has proven to be pleiotropic biological effects and may play pivotal role in numerous cardiovascular and metabolic diseases in the future. Vascular calcification (VC) is a …
Publication
A long noncoding RNA NR_045363 controls cardiomyocyte proliferation and cardiac repair
Long noncoding RNAs (lncRNAs) play important roles in the regulation of genes involved in cell proliferation. We have previously sought to more globally understand the differences of lncRNA expression between human fetal heart and adult heart to identify …
Publication
Low fat but not soy protein isolate was an effective intervention to reduce non-alcoholic fatty liver disease progression in C57BL/6J mice: Monitored by a novel quantitative ultrasound (QUS) method
Untreated non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) lead to irreversible liver damage. We hypothesized that a low-fat diet (LFD) or a high-fat diet (HFD) with soy protein isolate (SPI) would be an effective …
Publication
miRNA-130a improves cardiac function by down-regulating TNF-α expression in a rat model of heart failure.
OBJECTIVE To investigate the effect of MicroRNA (miRNA)-130a on cardiac function and the expression of tumor necrosis factor-α (TNF-α) in rats with heart failure. MATERIALS AND METHODS The rat heart failure model (n = 30) were established, then divided …
Publication
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction
Macrophages promote both injury and repair after myocardial infarction, but discriminating functions within mixed populations remains challenging. Here we used fate mapping, parabiosis and single-cell transcriptomics to demonstrate that at steady state, …
Publication
Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity
Given the association between high aerobic capacity and the prevention of metabolic diseases, elucidating the mechanisms by which high aerobic capacity regulates whole-body metabolic homeostasis is a major research challenge. Oxidative post-translational …
Publication
Maternal cardiac messenger RNA expression of extracellular matrix proteins in mice during pregnancy and the postpartum period
Pregnancy creates a condition of cardiac volume overload which leads to physiological sive analysis of extracellular matrix protein eccentric hypertrophy of the heart that is reversed in the postpartum period. Pathological (ECM) gene expression combined …