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Gallic Acid Suppresses Cardiac Hypertrophic Remodeling and Heart Failure
Scope: Gallic acid (GA) is a dietary phenolic acid found in tea, red wine, and some plants. It exhibits anti-oxidative and anti-inflammatory activities. Recent studies have revealed that GA has beneficial effects against several cardiovascular diseases; …
Publication
Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise
Regular exercise has widespread health benefits. Fundamental to these beneficial effects is the ability of the heart to intermittently and substantially increase its performance without incurring damage, but the underlying homeostatic mechanisms are …
Publication
Preliminary experience of the use of high-resolution skin ultrasound for the evaluation of extrathyroideal manifestations of Graves’ disease and response to UVA-1 phototherapy
Graves' orbitopathy (GO) and pre-tibial mixedema (PTM) are autoimmune manifestation sharing the same etiology and histopathology, a chronic course and a frustrating treatment. Current management include topical and systemic corticosteroid as first line …
Publication
Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome characterized by a preserved ejection fraction but increased diastolic stiffness and abnormalities of filling. Although the prevalence of HFpEF is high and continues to rise, no …
Publication
Sitagliptin improves cardiac function after myocardial infarction through activation of autophagy in streptozotocin-induced diabetic mice
OBJECTIVE: The aim of this study was to investigate the protective effect of sitagliptin on cardiac function in mice with diabetes and myocardial infarction (MI), and to explore its possible mechanism using the mouse models of diabetes and MI. MATERIALS …
Publication
Astragalus polysaccharide from Astragalus Melittin ameliorates inflammation via suppressing the activation of TLR-4/NF-κB p65 signal pathway and protects mice from CVB3-induced virus myocarditis
Inflammation plays a crucial role in regulating cardiomyopathy and injuries of coxsackievirus B3 (CVB3)-induced viral myocarditis (VM). It has been reported that Astragalus polysaccharide (AP) from Astragalus Melittin could inhabit inflammatory gene …
Publication
Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus
Thrombotic diseases rarely cause symptoms until advanced stage and sudden death. Thus, early detection of thrombus by a widely spread imaging modality can improve the prognosis and reduce mortality. Here, polymer microbubbles (MBs) made of degradable …
Publication
Cardioprotection via the skin; Nociceptor-Induced Conditioning Against Cardiac MI, in the NIC of time.
Timely reperfusion is still the most effective approach to limit infarct size in man. Despite advances in care and reduction in door-to-balloon times, nearly 25% of pa-tients develop heart failure post-MI, with its attendant morbidity and mortality. We …
Publication
Ratiometric Photoacoustic Nanoprobe for Bioimaging of Cu2+
Aberrant copper content implicates numerous diseases including Alzheimer's disease and Wilson’s disease. Conventional copper detection technologies are difficult to offer non-invasive and accurate deep tissue detection of copper. Here we report a …
Publication
Estrogen Dependent Disruption of Adiponectin-Connexin43 Signaling Underlies Exacerbated Myocardial Dysfunction in Diabetic Female Rats
The reasons for the higher severity of type 2 diabetes (T2DM)-associated cardiomyopathy in women, despite their inherent estrogen (E2)-dependent cardioprotection, remain unknown. We hypothesized that the reliance of the healthy females’ hearts on …