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The pretreatment of chronic restraint stress exerts little impact on the progression of heart failure in mice
Stress is a potent risk factor for depression. Chronic stress can exacerbate and induce symptoms of depression. Clinical studies suggested that depressive patients are more likely to develop cor- onary artery diseases. However, the causal relationship …
Publication
Effect of increasing liver blood flow on nanodrug clearance by the liver for enhanced antitumor therapy
The clinical applications of particulate drug delivery systems have demonstrated limited treatment out- comes, which is largely attributable to the elimination of such systems by the immune system, especially in the liver. Inspired by the mechanism of …
Publication
IFITM3 protects the heart during influenza virus infection
Influenza virus primarily targets the lungs, but dissemination and damage to heart tissue is also known to occur in severe infections. Despite this knowledge, influenza virus-induced cardiac pathogenesis and its underlying mechanisms have been difficult …
Publication
Ozone exposure during implantation increases serum bioactivity in HTR-8/SVneo trophoblasts
Implantation is a sensitive window in reproductive development during which disruptions may increase the risk of adverse pregnancy outcomes including intrauterine growth restriction. Ozone exposure during implantation in rats reduces fetal weight near the …
Publication
Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response
Recently, our group demonstrated that immobilized VEGF can capture flowing endothelial cells (ECs) fromthebloodin vitroandpromoteendothelializationandpatencyof acellular tissue–engineeredvessels (A-TEVs) into the arterial systemof an ovine animal model. …
Publication
Mast cell-deficiency protects mice from streptozotocin-induced diabetic cardiomyopathy
Mast cells (MCs) have been implicated in the pathogenesis of cardiometabolic diseases by releasing pro-inflammatory mediators. Patients and animals with diabetic cardiomyopathy (DCM) also show inflammatory cell accumulation in the heart. Here we detected …
Publication
Effects of interleukin-37 on cardiac function after myocardial infarction in mice.
BACKGROUND Interleukin-37 (IL-37) is a new discovered member of the interleukin family and plays anti-inflammatory effect in some inflammatory disease. A recent study found that IL-37 elevated significantly in peripheral blood of patients with acute …
Publication
Effects of interleukin-37 on cardiac function after myocardial infarction in mice
BACKGROUND Interleukin-37 (IL-37) is a new discovered member of the interleukin family and plays anti-inflammatory effect in some inflammatory disease. A recent study found that IL-37 elevated significantly in peripheral blood of patients with acute …
Publication
Alterations in cardiovascular function in an experimental model of lung fibrosis and pulmonary hypertension
Group III Pulmonary hypertension is observed in patients chronic lung diseases such as Chronic Obstructive Pulmonary Disease (COPD) or Idiopathic Pulmonary Fibrosis (IPF). Pulmonary Hypertension (PH) develops as a result of extensive pulmonary vascular …
Publication
Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy
The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast cancer with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant che- …