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AntagomiR-103/107 treatment affects cardiac function and metabolism
MicroRNA-103/107 regulate systemic glucose metabolism and insulin sensitivity. For this reason, inhibitory strategies for these microRNAs are currently being tested in clinical trials. Given the high metabolic demands of the heart and the abundant cardiac …
Publication
AdipoRon prevents <scp>l</scp> -thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway
Cardiac hypertrophy is a risk factor which can intrigue heart failure. In the present study, we explored whether AdipoRon attenuates isoprenaline (ISO) or L-thyroxine-induced cardiac hyper- trophy in Sprague–Dawley (SD) rats and whether the …
Publication
Evaluation of renal oxygen saturation using photoacoustic imaging for the early prediction of chronic renal function in a model of ischemia-induced acute kidney injury
PURPOSE: To evaluate the utility of photoacoustic imaging in measuring changes in renal oxygen saturation after ischemia-induced acute kidney injury, and to compare these measurements with histological findings and serum levels of kidney function. …
Publication
Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression
We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation of 8-HOA from COX-2-catalyzed DGLA peroxidation, which in turn inhibits cancer cell growth and migration. …
Publication
Ordered assemblies of Fe3O4 and a donor-acceptor-type π-conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects
We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. …
Publication
Species-dependent extracranial manifestations of a brain seeking breast cancer cell line
Purpose Metastatic brain tumors pose a severe problem in the treatment of patients with breast carci- noma. Preclinical models have been shown to play an important role in unraveling the underlying mechanisms behind the metastatic process and evaluation …
Publication
Recombinant human interleukin-1 receptor antagonist treatment protects rats from myocardial ischemia–reperfusion injury
The interleukin-1 (IL-1) signaling pathway plays a vital role in multiple mechanisms associated with myocardial ischemia–reperfusion (I/R) injury, including inflammation and apoptosis. An IL-1 receptor antagonist (IL-1Ra) can block IL-1 by competitive …
Publication
Chlorella-gold nanorods hydrogels generating photosynthesis-derived oxygen and mild heat for the treatment of hypoxic breast cancer
Hypoxic tumors are rarely cured because their low oxygen environment restricts the cytotoxicity of many chemotherapeutics by blocking the production of intracellular reactive oxygen species. Inspired by the highly efficient production of oxygen as a waste …
Publication
Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction
Increase in saturated fatty acid (SFA) content in membrane phospholipids dramatically affects membrane properties and cellular functioning. Wesought to determine whether exogenous SFA from the diet directly affects the degree of membrane phospholipid …
Publication
Gadolinium Doping Enhances the Photoacoustic Signal of Synthetic Melanin Nanoparticles: A Dual Modality Contrast Agent for Stem Cell Imaging
ABSTRACT: In this paper, we show that gadolinium-loaded synthetic melanin nanoparticles (Gd(III)-SMNPs) exhibit up to a 40-fold enhanced photoacoustic signal intensity relative to synthetic melanin alone and higher than other metal-chelated SMNPs. This …