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Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences.
BACKGROUND: Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction. We have previously shown that chronic hypoxia alters …
Publication
Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm.
We sought to characterize temporal gene expression changes in the murine angiotensin II (ANG II)-ApoE-/- model of abdominal aortic aneurysm (AAA). Aortic ultrasound measurements were obtained over the 28-day time-course. Harvested suprarenal aortic …
Publication
Assessment of flow distribution in the mouse fetal circulation at late gestation by high-frequency Doppler ultrasound
This study used high-frequency ultrasound to evaluate the flow distribution in the mouse fetal circulation at late gestation. We studied 12 fetuses (embryonic day 17.5) from 12 pregnant CD1 mice with 40 MHz ultrasound to assess the flow in 11 vessels …
Publication
In vivo bioimaging as a novel strategy to detect doxorubicin-induced damage to gonadal blood vessels.
INTRODUCTION: Chemotherapy may induce deleterious effects in normal tissues, leading to organ damage. Direct vascular injury is the least characterized side effect. Our aim was to establish a real-time, in vivo molecular imaging platform for evaluating …
Publication
Ovarian imaging in the mouse using ultrasound biomicroscopy (UBM): a validation study.
The mouse is a well accepted model for studies of human reproduction despite little being known about follicle dynamics in this species. Longitudinal studies of mouse folliculogenesis have been hampered by the lack of an appropriate imaging tool. …
Publication
Original Article Use of ultrasound biomicroscopy to evaluate induced ovarian follicular growth and ovulation in mice
Original Article Use of ultrasound biomicroscopy to evaluate induced ovarian follicular growth and ovulation in mice …
Publication
In vivo imaging of cumulus-oocyte-complexes and small ovarian follicles in cattle using ultrasonic biomicroscopy.
The objectives of this study were to: (1) evaluate the feasibility of ultrasonic biomicroscopy (UBM) for imaging ovarian follicles in vivo in cows and heifers, (2) compare the transvaginal to the transrectal approach, (3) compare the number of follicles …
Publication
Calcific aortic valve stenosis: methods, models, and mechanisms.
Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major paradigm shift in the field. CAVS was thought to be a passive, …
Publication
Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old Mice
Aging leads to a high prevalence of glucose intolerance and cardiovascular diseases, with oxidative stress playing a potential role. Resveratrol has shown promising effects on glucose tolerance and tends to improve endothelial function in elderly …
Publication
The innate immune system contributes to tissue-engineered vascular graft performance
The first clinical trial of tissue-engineered vascular grafts (TEVGs) identified stenosis as the primary cause of graft failure. In this study, we aimed to elucidate the role of the host immune response in the development of stenosis using a murine model …