In this study was evaluated the chronic cardiac effects of a formulation developed by including angiotensin(Ang)-(1–7) in hydroxypropyl β -cyclodextrin (HP β CD), in infarcted rats. Myocardial infarction (MI) was induced by left coronary artery occlusion. …

Radiotherapy of intrathoracic and chest wall tumors may lead to exposure of the heart to ionizing radiation, resulting in radiation-induced heart diseases (RIHD). The main manifestations of RIHD become apparent many years after treatment and include …

OBJECTIVE: Velocity vector imaging can be used to assess longitudinal common carotid artery (CCA) wall movement (tLoD) in man. To deepen our mechanistic understanding, we aimed to adapt this technique to atherosclerotic prone mice models. METHODS: 46 mice …

INTRODUCTION: Many cardiovascular diseases are closely associated with the mechanical properties of arterial wall and hemodynamic parameters. Simultaneous measurements of the arterial strain and flow pattern may aid diagnosis of cardiovascular diseases …

The current therapeutic options for acute decompensated heart failure are limited to afterload reducers and positive inotropes. The latter increases myocardial contractility through changes in myocyte calcium (Ca²⁺) handling (mostly through stimulation of …

Unlike the adjustable gastric banding procedure (AGB), Roux-en-Y gastric bypass surgery (RYGBP) in humans has an intriguing effect: a rapid and substantial control of type 2 diabetes mellitus (T2DM). We performed gastric lap-band (GLB) and entero-gastro …

Visualization of molecular composition and functionality of cancer cells using nanoparticle-augmented ultrasound-guided photoacoustics …

BACKGROUND: Molecular imaging is a fast emerging technology allowing noninvasive detection of vascular pathologies. However, imaging modalities offering high resolution currently do not allow real-time imaging. We hypothesized that contrast-enhanced …

Purpose: Materials and Methods: Results: Conclusion: To evaluate in vivo whole-body biodistribution of micro- bubbles (MBs) targeted to tumor angiogenesis–related vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by using dynamic …

UNLABELLED: Targeted contrast-enhanced ultrasound imaging is increasingly being recognized as a powerful imaging tool for the detection and quantification of tumor angiogenesis at the molecular level. The purpose of this study was to develop and test a …