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Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system.
Radiotherapy of intrathoracic and chest wall tumors may lead to exposure of the heart to ionizing radiation, resulting in radiation-induced heart diseases (RIHD). The main manifestations of RIHD become apparent many years after treatment and include …
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Longitudinal common carotid artery wall motion is associated with plaque burden in man and mouse
OBJECTIVE: Velocity vector imaging can be used to assess longitudinal common carotid artery (CCA) wall movement (tLoD) in man. To deepen our mechanistic understanding, we aimed to adapt this technique to atherosclerotic prone mice models. METHODS: 46 mice …
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A 2D non-invasive ultrasonic method for simultaneous measurement of arterial strain and flow pattern.
INTRODUCTION: Many cardiovascular diseases are closely associated with the mechanical properties of arterial wall and hemodynamic parameters. Simultaneous measurements of the arterial strain and flow pattern may aid diagnosis of cardiovascular diseases …
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Probenecid as a Noninjurious Positive Inotrope in an Ischemic Heart Disease Murine Model
The current therapeutic options for acute decompensated heart failure are limited to afterload reducers and positive inotropes. The latter increases myocardial contractility through changes in myocyte calcium (Ca²⁺) handling (mostly through stimulation of …
Publication
Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.
Unlike the adjustable gastric banding procedure (AGB), Roux-en-Y gastric bypass surgery (RYGBP) in humans has an intriguing effect: a rapid and substantial control of type 2 diabetes mellitus (T2DM). We performed gastric lap-band (GLB) and entero-gastro …
Publication
Visualization of molecular composition and functionality of cancer cells using nanoparticle-augmented ultrasound-guided photoacoustics
Visualization of molecular composition and functionality of cancer cells using nanoparticle-augmented ultrasound-guided photoacoustics …
Publication
Novel Single-Chain Antibody-Targeted Microbubbles for Molecular Ultrasound Imaging of Thrombosis: Validation of a Unique Noninvasive Method for Rapid and Sensitive Detection of Thrombi and Monitoring of Success or Failure of Thrombolysis in Mice
BACKGROUND: Molecular imaging is a fast emerging technology allowing noninvasive detection of vascular pathologies. However, imaging modalities offering high resolution currently do not allow real-time imaging. We hypothesized that contrast-enhanced …
Publication
Targeted Microbubbles for Imaging Tumor Angiogenesis: assessment of whole body biodistribution with dynamic micro-PET in mice.
Purpose: Materials and Methods: Results: Conclusion: To evaluate in vivo whole-body biodistribution of micro- bubbles (MBs) targeted to tumor angiogenesis–related vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by using dynamic …
Publication
Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast microbubbles conjugated to integrin-binding knottin peptides.
UNLABELLED: Targeted contrast-enhanced ultrasound imaging is increasingly being recognized as a powerful imaging tool for the detection and quantification of tumor angiogenesis at the molecular level. The purpose of this study was to develop and test a …
Publication
Dual-targeted Contrast Agent for US Assessment of Tumor Angiogenesis in Vivo
Purpose: To develop and validate a dual-targeted ultrasound imaging agent that attaches to both vascular endothelial growth factor receptor-2 (VEGFR2) and αvβ3-integrin, and to compare the ultrasonic imaging signal obtained from this dual-targeted agent …