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Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium
The fetal intestinal mucosa is characterized by elevated Toll-like re- ceptor 4 (TLR4) expression, which can lead to the development of necrotizing enterocolitis (NEC)—a devastating inflammatory dis- ease of the premature intestine—upon exposure to …
Publication
<em>In Utero</em> Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
The formation and perfusion of developing renal blood vessels (apart from glomeruli) are greatly understudied. As vasculature develops via angiogenesis (which is the branching off of major vessels) and vasculogenesis ( in vi de no v o vessel formation), …
Publication
High-Frequency Ultrasound-Guided Injection for the Generation of a Novel Orthotopic Mouse Model of Human Thyroid Carcinoma
Background: Thyroid carcinoma is the most common endocrine malignancy and has an increasing incidence. High-frequency ultrasound (HFUS) has a spatial resolution of 30 lm, which is a property that has been exploited for thyroid visualization and analysis …
Publication
Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound
Ultrasound contrast-enhanced imaging can convey essential quantitative information regarding tissue vascularity and perfusion and, in targeted applications, facilitate the detection and measure of vascular biomarkers at the molecular level. Within the …
Publication
Very High Resolution Ultrasound Imaging for Real-Time Quantitative Visualization of Vascular Disruption after Spinal Cord Injury
Spinal cord injury (SCI) is characterized by vascular disruption with intramedullary hemorrhage, alterations in blood- spinal cord barrier integrity, and perilesional ischemia. A safe and easily applied imaging technique to quantify evolving intraspinal …
Publication
Preclinical efficacy of bevacizumab with CRLX101, an investigational nanoparticle-drug conjugate, in treatment of metastatic triple-negative breast cancer
VEGF-pathway targeting antiangiogenic drugs, such as bevacizumab, when combined with chemotherapy have changed clinical practice for the treatment of a broad spectrum of human cancers. However, adaptive resistance often develops and one major mechanism is …
Publication
A Robust Design for Cellular Vehicles of Gold Nanorods for Multimodal Imaging
The pursuit of more selectivity in the delivery of plasmonic particles to tumors is critical before their penetration into clinical applications as the photoacoustic imaging and the photothermal ablation of cancer. As their direct infusion into the …
Publication
Strategies for non-invasive imaging of polymeric biomaterial in vascular tissue engineering and regenerative medicine using ultrasound and photoacoustic techniques
The ability of new polymericmaterials to provide excellent biomechanical properties expanded their potential for biomedical applications enormously. The use of non-invasive imaging modalities could provide crucial information to monitor the …
Publication
Photoacoustic imaging of angiogenesis in a subcutaneous islet transplant site in a murine model a subcutaneous islet transplant site in a murine model
Photoacoustic imaging of angiogenesis in a subcutaneous islet transplant site in a murine model a subcutaneous islet transplant site in a murine …
Publication
Gold Nanoparticle Coated Carbon Nanotube Ring with Enhanced Raman Scattering and Photothermal Conversion Property for Theranostic Applications
We report a new type of carbon nanotube ring (CNTR) coated with gold nanoparticles (CNTR@AuNPs) using CNTR as a template and surface attached redox-active polymer as a reducing agent. This nanostructure of CNTR bundle embedded in the gap of closely …