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Naturally occurring p16 Ink4a -positive cells shorten healthy lifespan
0 0 M o n t h 2 0 1 6 | V o L 0 0 0 | n A t U R E | 1 Cellular senescence is a well-established cancer defence mechanism that has also been proposed to have roles in ageing and age-associated diseases, presumably through the depletion of stem and …
Publication
Nanotherapy silencing the interleukin-8 gene produces regression of prostate cancer by inhibition of angiogenesis
Interleukin-8 (IL-8) is a proangiogenic cytokine associated with aggressive prostate cancer (CaP). We detected high levels of IL-8 in sera from patients with CaP compared to healthy controls and patients with benign prostatic hypertrophy. This study …
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Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess
Fetoplacental glucocorticoid overexposure is a significant mecha- nism underlying fetal growth restriction and the programming of adverse health outcomes in the adult. Placental glucocorticoid inactivation by 11β-hydroxysteroid dehydrogenase type 2 (11β- …
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High-resolution renal perfusion mapping using contrast-enhanced ultrasonography in ischemia-reperfusion injury monitors changes in renal microperfusion
Alterations in renal microperfusion play an important role in the development of acute kidney injury with long- term consequences. Here we used contrast-enhanced ultrasonography as a novel method for depicting intrarenal distribution of blood flow. After …
Publication
Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury
Myocardial infarction results in compromised myocardial function and heart failure owing to insufficient cardiomyocyte self-renewal1. Unlike many vertebrates, mammalian hearts have only a transient neonatal renewal capacity2. Reactivating primitive …
Publication
Human Chorionic Gonadotropin Has Anti-Inflammatory Effects at the Maternal-Fetal Interface and Prevents Endotoxin-Induced Preterm Birth, but Causes Dystocia and Fetal Compromise in Mice
Human chorionic gonadotropin (hCG) is implicated in the maintenance of uterine quiescence by down-regulating myometrial gap junctions during pregnancy, and it was considered as a strategy to prevent preterm birth after the occurrence of preterm labor. …
Publication
Novel effects of simvastatin on uterine fibroid tumors: In vitro and patient-derived xenograft mouse model study
Objective Uterine leiomyomas represent a common gynecologic problem with no satisfactory long-term medical treatment. The purpose of this study is to examine the effects of simvastatin on uterine leiomyoma, both in vitro and in vivo. Study Design This is …
Publication
Functional and anatomical evidence of cerebral tissue hypoxia in young sickle cell anemia mice
Cerebral ischemia is a significant source of morbidity in children with sickle cell anemia; however, the mechanism of injury is poorly understood. Increased cerebral blood flow and low hemoglobin levels in children with sickle cell anemia are associated …
Publication
LOW-MAGNITUDE HIGH-FREQUENCY VIBRATION ENHANCED MESENCHYMAL STEM CELL RECRUITMENT IN OSTEOPOROTIC FRACTURE HEALING THROUGH THE SDF-1 / CXCR4 PATHWAY
Low-magnitude high-frequency vibration (LMHFV) has been proven to promote osteoporotic fracture healing. Mechanical stimulation was reported to enhance SDF-1/ CXCR4 signalling in mesenchymal stem cells (MSCs). We hypothesised that LMHFV promoted …
Publication
Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies
The efficiency of assisted reproductive technologies (ARTs) in nonhuman primates is low due to no screening criterions for selecting sperm, oocyte, and embryo as well as its surrogate mothers. Here we analyzed 15 pairs of pregnant and non-pregnant …