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A biodegradable synthetic graft for small arteries matches the performance of autologous vein in rat carotid arteries
Autologous veins are the most widely used grafts for bypassing small arteries in coronary and peripheral arterial occlusive diseases. However, they have limited availability and cause donor- site morbidity. Here, we report a direct comparison of acellular …
Publication
The role of Parkin protein in cardiac function and ventricular remodeling in myocardial infarction rats
OBJECTIVE: This study aims to ex- plore the role and the mechanism of Parkin pro- tein in cardiac function and ventricular remodel- ing in myocardial infarction (MI) rats, and to pro- vide a new sight for the treatment of myocardi- al infarction. …
Publication
The Murine Dialysis Fistula Model Exhibits a Senescence Phenotype: Pathobiologic Mechanisms and Therapeutic Potential
There is no therapy that promotes maturation and functionality of a dialysis arteriovenous fistula (AVF). The search for such therapies largely relies on evaluating vascular responses and putative therapies in experimental AVFs. We studied an AVF in mice …
Publication
CAVEOLIN-3 KO DISRUPTS T-TUBULE STRUCTURE AND DECREASES T-TUBULAR I Ca DENSITY IN MOUSE VENTRICULAR MYOCYTES
Caveolin-3 (Cav-3) is a protein that has been implicated in t-tubule formation and function in cardiac ventricular myocytes. In cardiac hypertrophy and failure, Cav-3 expression decreases, t-tubule structure is disrupted and excitation-contraction …
Publication
The involvement of AQP1 in myocardial edema induced by pressure overload in mice
OBJECTIVE: To investigate the effect of aquaporin-1 (AQP1) on heart edema in- duced by transverse aortic constriction (TAC) in mice, and to explore whether inhibiting the ex- pression of AQP1 could attenuate myocardial edema and improve cardiac function. …
Publication
Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo
Photoacoustic (PA) computed tomography (PACT) benefits from genetically encoded probes with photochromic behavior, which dramatically increase detection sensitivity and specificity through photoswitching and differential imaging. Starting with a DrBphP …
Publication
Disseminated injection of vincristine-loaded silk gel improves the suppression of neuroblastoma tumor growth
Background: Advanced-stage neuroblastoma patients require multiagent chemotherapy. Intratumoral implantation of vincristine-loaded silk gel uses local diffusion to decrease orthotopic neuroblastoma tumor growth in mice. We hypothesize that injecting …
Publication
Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation
Dilated cardiomyopathy (DCM) is a severe disorder caused by medications or genetic mutations. D5 dopamine receptor (D5R) gene knockout (D5-/-) mice have cardiac hypertrophy and high blood pressure. To investigate the role and mechanism by which the D5R …
Publication
Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure
Heart failure (HF) is a shared manifestation of several cardiovas- cular pathologies, including hypertension and myocardial infarc- tion, and a limited repertoire of treatment modalities entails that the associated morbidity and mortality remain high. …
Publication
Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Chronic Ethanol-induced Cardiac Fibrosis by Restoring Autophagic Flux
BACKGROUND: Chronic drinking leads to myocardial contractile dysfunction and dilated cardiomyopathy, and cardiac fibrosis is a consequence of these alcoholic injuries. Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids to less bioactive …