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Publication
Gold nanoparticles for photoacoustic imaging.
Photoacoustic (PA) imaging is a biomedical imaging modality that provides functional information regarding the cellular and molecular signatures of tissue by using endogenous and exogenous contrast agents. There has been tremendous effort devoted to the …
Publication
In vitro photoacoustic visualization of myocardial ablation lesions
Background—Radiofrequency (RF) ablation to treat atrial arrhythmia is limited by an inability to reliably assess lesion durability and transmurality. Objective—Determine feasibility of photoacoustic characterization of myocardial ablation lesions in …
Publication
Biomedical photoacoustics beyond thermal expansion using triggered nanodroplet vaporization for contrast-enhanced imaging
Since being discovered by Alexander Bell, photoacoustics may again be seeing major resurgence in biomedical imaging. Photoacoustics is a non-ionizing, functional imaging modality capable of high contrast images of optical absorption at depths …
Publication
Dual In Vivo Photoacoustic and Fluorescence Imaging of Assessment , and Surgical Guidance
Biomarker-specific imaging probes offer ways to improve molecular diagnosis, intraoperative margin assessment, and tumor resection. Fluorescence and photoacoustic imaging probes are of particular interest for clinical applications because the combination …
Publication
Aggregate Enhanced Trimodal Porphyrin Shell Microbubbles for Ultrasound, Photoacoustic, and Fluorescence Imaging
Microbubbles (MBs) are currently used as ultrasound (US) contrast agents and as delivery vehicles for site-specific US-triggered drug and gene delivery. Multimodal US-based imaging methods have been applied preclinically to assess and validate the …
Publication
Handheld photoacoustic probe to detect both melanoma depth and volume at high speed in vivo
In the United States, Black infants have significantly worse birth outcomes than White infants. Over the past decades, public health efforts to address these disparities have focused primarily on increasing access to prenatal care, however, this has not …
Publication
In vivo Ultrasound and Photoacoustic Monitoring of Mesenchymal Stem Cells Labeled with Gold Nanotracers
Longitudinal monitoring of cells is required in order to understand the role of delivered stem cells in therapeutic neovascularization. However, there is not an imaging technique that is capable of quantitative, longitudinal assessment of stem cell …
Publication
What is new in nanoparticle-based photoacoustic imaging?
Photoacoustic imaging combines the high temporal and spatial resolution of ultrasound with the good contrast and spectral tuning of optical imaging. Contrast agents are used in photoacoustic imaging to further increase the contrast and specificity of …
Publication
Stable J-aggregation enabled dual photoacoustic and fluorescence nanoparticles for intraoperative cancer imaging
J-aggregates display nanoscale optical properties which enable their use in fluorescence and photo- acoustic imaging applications. However, control over their optical properties in an in vivo setting is ham- pered by the conformational lability of the …
Publication
Prediction of Tumor Recurrence and Therapy Monitoring Using Ultrasound-Guided Photoacoustic Imaging
Selection and design of individualized treatments remains a key goal in cancer therapeutics; prediction of response and tumor recurrence following a given therapy provides a basis for subsequent personalized treatment design. We demonstrate an approach …