Search
Publication
Intratendinous Injection of Hyaluronate Induces Acute Inflammation: A Possible Detrimental Effect
Abstract Hyaluronate (HA) is therapeutic for tendinopathy, but an intratendinous HA injection is usu- ally painful; thus, it is not suggested for clinical practice. However, there are no studies on the histopathological changes after an intratendinous HA …
Publication
Monitoring the Growth of an Orthotopic Tumour Xenograft Model: Multi-Modal Imaging Assessment with Benchtop MRI (1T), High-Field MRI (9.4T), Ultrasound and Bioluminescence
Background: Research using orthotopic and transgenicmodels of cancer requires imaging methods to non-invasively quantify tumour burden. As the choice of appropriate imaging modality is wide-ranging, this study aimed to compare low-field (1T) magnetic …
Publication
Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare disease of the pulmonary vasculature characterized by endothelial cell apoptosis, smooth muscle proliferation and obliteration of pulmonary arterioles. This in turn results in right ventricular (RV) failure, …
Publication
Effects of 1, 25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice
BACKGROUND/AIMS: Myocarditis is an important inflammatory disease of the heart which causes life-threatening conditions. 1, 25(OH)2 D3 has effects on multiple systems and diseases. The present study was aimed to investigate the effect of 1, 25(OH)2 D3 on …
Publication
Diastolic dysfunction and cardiac troponin I decrease in aging hearts
abstract Cardiac tropnoin I (cTnI) plays a critical role in the regulation of diastolic function, and its low expression may result in cardiac diastolic dysfunction, which is the most common form of cardiovascular disorders in older adults. In this study, …
Publication
Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway
BACKGROUND AND PURPOSE Endoplasmic reticulum (ER) stress is increasingly recognized as an important causal factor of many diseases. Targeting ER stress has now emerged as a new therapeutic strategy for treating cardiovascular diseases. Here we …
Publication
Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice
Familial hypertrophic cardiomyopathy (HCM) is a disease of the sarcomere and may lead to hypertrophic, dilated, restrictive, and/or arrhythmogenic cardiomyopathy, 38 congestive heart failure, or sudden cardiac death. We hypothesized that hearts from 39 …
Publication
Quantification of Endothelial αvβ3 Expression with High-Frequency Ultrasound and Targeted Microbubbles: In Vitro and In Vivo Studies
Angiogenesis is a critical feature of plaque development in atherosclerosis and might play a key role in both the initiation and later rupture of plaques. The precursory molecular or cellular pro-angiogenic events that initiate plaque growth and that …
Publication
Intracardial embryonic delivery of developmental modifiers in utero
Our knowledge of organ ontogeny is largely based on loss-of-function (knockout) or gain-of-function (transgenesis) approaches. However, developmental modulators such as proteins, mRNAs, microRNAs(miRNAs), small interfering RNAs, and other small molecules …
Publication
ROR Beta induces barrel-like neuronal clusters in the developing neocortex
Neurons in layer IV of the rodent whisker somatosensory cortex are tangentially organized in periodic clusters called barrels, each of which is innervated by thalamocortical axons transmitting sensory information from a single principal whisker, together …