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Accelerated cardiac remodeling in desmoplakin transgenic mice in response to endurance exercise is associated with perturbed Wnt/β-catenin signaling
BACKGROUND: Arrhythmogenic ventricular cardiomyopathy (AVC) is a frequent underlying cause for arrhythmias and sudden cardiac death especially during intense exercise. The mechanisms involved remain largely unknown. OBJECTIVE: To investigate how chronic …
Publication
Early cardiac dysfunction in the type 1 diabetic heart using speckle-tracking based strain imaging.
Enhanced sensitivity in echocardiographic analyses may allow for early detection of changes in cardiac function beyond the detection limits of conventional echocardiographic analyses, particularly in a small animal model. The goal of this study was to …
Publication
Myocardial dysfunction occurs prior to changes in ventricular geometry in mice with chronic kidney disease (CKD)
Uremic cardiomyopathy is responsible for high morbidity and mortality rates among patients with chronic kidney disease (CKD), but the underlying mechanisms contributing to this complex phenotype are incompletely understood. Myocardial deformation analyses …
Publication
Speckle Tracking Based Strain Analysis Is Sensitive for Early Detection of Pathological Cardiac Hypertrophy
Cardiac hypertrophy is a key pathological process of many cardiac diseases. However, early detection of cardiac hypertrophy is difficult by the currently used non-invasive method and new approaches are in urgent need for efficient diagnosis of cardiac …
Publication
Krox20 heterozygous mice: A model of aortic regurgitation associated with decreased expression of fibrillar collagen genes
Abstract BACKGROUND: The mechanism involved in the onset of aortic valve (AoV) disease remains unclear despite its poor prognosis and frequency. Recently, we reported that Krox20 (EGR2 in humans) is involved in AoV development and dysfunction. AIM: …
Publication
Inhibition of late Na + current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats
Late Na current (INaL) is enhanced in myocytes of animals with chronic heart failure and patients with hypertrophic cardiomyopathy. To define the role of INaL in diastolic heart failure, the effects of GS-458967 (GS-967), a potent INaL inhibitor on …
Publication
Tumor priming using metronomic chemotherapy with neovasculature-targeted, Nanoparticulate paclitaxel
Normalization of the tumor microenvironment is a promising approach to render conventional chemotherapy more effective. Although passively targeted drug nanocarriers have been investigated to this end, actively targeted tumor priming remains to be …
Publication
Follistatin‐like 1 promotes cardiac fibroblast activation and protects the heart from rupture
Follistatin-like 1 (Fstl1) is a secreted protein that is acutely induced in heart following myocardial infarction (MI). In this study, we investigated cell type-specific regulation of Fstl1 and its function in a murine model of MI. Fstl1 was robustly …
Publication
Splenic release of platelets contributes to increased circulating platelet size and inflammation after myocardial infarction
Acute myocardial infarction (AMI) is characterized by a rapid increase in circulating platelet size but the mechanism for this is unclear. Large platelets are hyperactive and associated with adverse clinical outcomes. We determined mean platelet volume …
Publication
Exercise Prevents Diet-induced Cellular Senescence in Adipose Tissue
Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however, the extent to which they affect the behavior and accretion of senescent cells within distinct …