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Inhibition of prolyl hydroxylase domain proteins selectively enhances venous thrombus neovascularisation
BACKGROUND: Hypoxia within acute venous thrombi is thought to drive resolution through stabilisation of hypoxia inducible factor 1 alpha (HIF1α). Prolyl hydroxylase domain (PHD) isoforms are critical regulators of HIF1α stability. Non-selective inhibition …
Publication
Radioiodinated Pentixather for SPECT Imaging of the Chemokine Receptor CXCR4 Expression in Rat Myocardial Infarction/Reperfusion Models
The purpose of this study is to develop a specific CXCR4-targeting radioiodinated agent (125I/131I-pentixather) for single-photon emission computed tomography (SPECT) imaging of CXCR4 expression in myocardial infarction/reperfusion (MI/R) rat models. …
Publication
Endoglin‑targeted contrast‑enhanced ultrasound imaging in hepatoblastoma xenografts
Angiogenesis is required for the growth of hepa- toblastoma (HB). In the present study, an ultrasonic contrast agent, microbubbles (MB), was combined with an endoglin antibody, and then injected into nude mice with HB. This was conducted to detect …
Publication
A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21
Adipocytes play important roles in regulating cardiovascular health and disease. However, the molecular mechanism underlying the endocrine role of brown adipose tissue (BAT) in pathological cardiac remodeling remains unknown. Herein we show that adenosine …
Publication
Obstruction of ventricular Ca 2+ -dependent arrhythmogenicity by IP 3 - triggered SR-Ca 2+ release
Augmented inositol 1,4,5-trisphosphate (IP3) receptor (IP3R2) function has been linked to a variety of cardiac pathologies including cardiac arrhythmias. The functional role of IP3- induced Ca2+ release (IP3ICR) within ventricular excitation-contraction …
Publication
High-Frequency Micro-Ultrasound Imaging and Optical Topographic Imaging for Spinal Surgery: Initial Experiences
High frequency micro-ultrasound (µUS) transducers with central frequencies up to 50 MHz facilitate dynamic visualization of patient anatomy with minimal disruption of the surgical work flow. Micro-ultrasound improves spatial resolution over conventional …
Publication
Heat-shock transcription factor 1 is critically involved in the ischaemia-induced cardiac hypertrophy via JAK2/STAT3 pathway
Cardiac hypertrophy after myocardial infarction (MI) is an independent risk factor for heart failure. Regression of cardiac hypertrophy has emerged as a promising strategy in the treatment of MI patients. Here, we have been suggested that heat- shock …
Publication
Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity
Background-—Desmin filament proteins interlink the contractile myofibrillar apparatus with mitochondria, nuclei and the sarcolemma. Mutations in the human desmin gene cause cardiac disease, remodeling, and heart failure but the pathophysiological …
Publication
Sex Differences in Depression-Like Behavior and Neuroinflammation in Rats Post MI: Role of Estrogens
Patients with heart failure (HF) have a high prevalence of depression associated with a worse prognosis, particularly in older women. This study evaluated whether sex and estrogens affect depression-like behavior and associated neuroinflammation induced …
Publication
Immune response mediates cardiac dysfunction after traumatic brain injury
Cardiovascular complications are common after TBI and are associated with increased morbidity and mortality. In this study, we investigated the possible role of the immune system in mediating cardiac dysfunction post-TBI in mice. Adult male C57BL/6J mice …