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Publication
Endometrial regeneration using cell sheet transplantation techniques in rats facilitates successful fertilization and pregnancy
Objective: To regenerate functional endometrium tissue using “cell sheet” techniques as a regenerative medicine approach to address endometrial disorders causing female factor infertility. Design: In vivo experimental study. Setting: Preclinical surgical …
Publication
Age-Dependent Cardiac Function during Experimental Sepsis: Effect of Pharmacological Activation of AMP-Activated Protein Kinase by AICAR
Age represents a major risk factor of multiple organ failure, including cardiac dysfunction, in patients with sepsis. AMP-activated protein kinase (AMPK) is a crucial regulator of energy homeostasis, which controls mitochondrial biogenesis by activation …
Publication
Uremia increases QRS duration after β -adrenergic stimulation in mice
Chronic kidney disease (CKD) and uremia increase the risk of heart disease and sudden cardiac death. Coronary artery disease can only partly account for this. The remaining mechanistic links between CKD and sudden death are elu- sive, but may involve …
Publication
MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7
The excessive inflammation triggered by damage-associated molecular patterns (DAMPs) after myocardial infarction (MI) is responsible for the development of cardiac dysfunction and adverse remodeling, while the mechanisms by which inflammation is fine …
Publication
Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart
Background. Peptide infusions of the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3) have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuited for chronic …
Publication
Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function
Patients with acute myocardial infarction receive a P2Y12 receptor antagonist prior to reperfusion, a treatment that has reduced, but not eliminated, mortality, or heart failure. We tested whether the caspase-1 inhibitor VX-765 given at reperfu- sion (a …
Publication
Improved heart failure by Rhein lysinate is associated with p38MAPK pathway
The present study aimed to explore the role of Rhein lysinate (RHL) in neonatal rat ventricular myocytes (NRVMs) and congestive heart failure induced by co-arctation of the abdominal aorta. Male Sprague-Dawley rats were divided into 3 groups randomly: …
Publication
Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats
Cardiorespiratory fitness (CRF) inversely predicts cardiovascular (CV) mortal- ity and CRF is impaired in people with type 2 diabetes (T2D). Aerobic exer- cise training (ET) improves CRF and is associated with decreased risk of premature death in healthy …
Publication
Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer
Prostate Cancer (PCa) is the second most common and fifth cause of cancer-related mortality in males in Western Countries. The development of innovative tools for an early, more precise and noninvasive diagnosis is a medical need. Vascular volume (Vv) and …
Publication
Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis
Myocardial infarction (MI) is a major cause of death in Western countries and finding new strategies for its prevention and treatment is thus of high priority. In a previous study, we have demonstrated a pathophysiologic relevance for the heterophilic …