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Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury
Fibroblast growth factor (FGF) signaling is cardioprotective in various models of myocardial infarction. FGF receptors (FGFRs) are expressed in multiple cell types in the adult heart, but the cell type-specific FGFR signaling that mediates different …
Publication
KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation
KMT2D, which encodes a histone H3K4 methyltransferase, has been implicated in human congenital heart disease in the context of Kabuki syndrome. However, its role in heart development is not understood. Here, we demonstrate a requirement for KMT2D in …
Publication
Reduction in mitochondrial iron alleviates cardiac damage during injury.
Excess cellular iron increases reactive oxygen species (ROS) production and causes cellular damage. Mitochondria are the major site of iron metabolism and ROS production; however, few studies have investigated the role of mitochondrial iron in the …
Publication
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger1 Regulates its Activity by Dephosphorylating Serine 68 Phosphorylated Phospholemman.
The sodium (Na(+))-calcium (Ca(2+)) exchanger 1 (NCX1) is an important regulator of intracellular Ca(2+) homeostasis. Serine 68 phosphorylated phospholemman (pSer-68-PLM) inhibits NCX1 activity. In the context of Na(+)/K(+) ATPase (NKA) regulation, …
Publication
Secreted frizzled-related protein 5 diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury
Wnt signaling has diverse actions in cardiovascular development and disease processes. Secreted frizzled-related protein 5 (Sfrp5) has been shown to function as an extracellular inhibitor of non-canonical Wnt signaling that is expressed at relatively high …
Publication
Cardiomyocyte-specific overexpression of oestrogen receptor improves survival and cardiac function after myocardial infarction in female and male mice
BACKGROUND: Estrogen receptor beta (ERβ) activation has been shown to be cardioprotective, but the involved cell types and mechanisms are not understood. To investigate whether ERβ restricted to cardiomyocytes contributes to observed cardioprotection, we …
Publication
Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway
It has been reported that oncostatin M (OSM) could initiate cardiomyocyte dedifferentiation both in vivo and in vitro. OSM-induced cardiomyocyte dedifferentiation might be a new target for the treatment of diabetic cardiomyopathy (DCM). This study was …
Publication
RGS2 squelches vascular G i/o and G q signaling to modulate myogenic tone and promote uterine blood flow
Uterine artery blood flow (UABF) is critical to maintaining uterine perfusion in nonpregnant states and for uteroplacental delivery of nutrients and oxygen to the fetus during pregnancy. Impaired UABF is implicated in infertility and several pregnancy …
Publication
Cardiac remodeling in the mouse model of Marfan syndrome develops into two distinctive phenotypes
Marfan syndrome (MFS) is a systemic disorder of connective tissue caused by mutations in fibrillin-1. Cardiac dysfunction in MFS has not been characterized halting the development of therapies of cardiac complication in MFS. We aimed to study the …
Publication
LRRC10 is required to maintain cardiac function in response to pressure overload
We previously reported that the cardiomyocyte-specific protein, Leucine-rich repeat containing 10 (LRRC10), has critical functions in the mammalian heart. Here, we tested the role of LRRC10 in the response of the heart to biomechanical stress by …