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Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe
Photoacoustic tomography (PAT) of genetically encoded probes allows for imaging of targeted biological processes deep in tissues with high spatial resolution; however, high background signals from blood can limit the achievable detection sensitivity. Here …
Publication
Combined blockade of angiotensin II type 1 receptor and activation of peroxisome proliferator-activated receptor-?? by telmisartan effectively inhibits vascularization and growth of murine endometriosis-like lesions
STUDY QUESTION: Is telmisartan effective in the treatment of endometriosis?\n\nSUMMARY ANSWER: Combined blockade of angiotensin II type 1 receptor (AT1R) and activation of peroxisome proliferator-activated receptor (PPAR)-γ by telmisartan inhibits …
Publication
High-Resolution Ultrasound Imaging: A Novel Technique for the Noninvasive in Vivo Analysis of Endometriotic Lesion and Cyst Formation in Small Animal Models
Endometriosis, the presence of endometrial tissue at ectopic sites, is a highly prevalent gynecological dis- ease severely affecting a patient’s quality of life. To analyze the mechanisms involved in the disease and to identify new molecular targets for …
Publication
Cardiovascular Imaging in Mice
The mouse is the mammalian model of choice for investigating cardiovascular biology, given our ability to manipulate it by genetic, pharmacologic, mechanical, and environmental means. Imaging is an important approach to phenotyping both function and …
Publication
Resveratrol is a potent inhibitor of vascularization and cell proliferation in experimental endometriosis
STUDY QUESTION: Does the phytochemical compound resveratrol inhibit vascularization of endometriotic lesions?\n\nSUMMARY ANSWER: Resveratrol suppresses the development of new microvessels in endometriotic lesions by inhibiting endothelial cell …
Publication
Quantification of bound microbubbles in ultrasound molecular imaging
Molecular markers associated with diseases can be visualized and quantified noninvasively with targeted ultrasound contrast agent (t-UCA) consisting of microbubbles (MBs) that can bind to specific molecular targets. Techniques used for quantifying t-UCA …
Publication
Nonlinear contrast imaging with an array-based micro-ultrasound system
The main goal of this study was to determine the optimal strategy for a real-time nonlinear contrast mode for small-animal imaging at high frequencies, on a new array-based micro-ultrasound system. Previously reported contrast imaging at frequencies above …
Publication
Biosynthesis of lipid A in Escherichia coli: Acyl carrier protein-dependent incorporation of laurate and myristate
In previous studies we described enzyme(s) from Escherichia coli that transfer two 3-deoxy-D-manno-octulosonate (KDO) residues from two CMP-KDO molecules to a tetraacyldisaccharide-1,4'-bis-phosphate precursor of lipid A, termed lipid IVA (Brozek, K. A., …
Publication
Live Observation of Atherosclerotic Plaque Disruption in Apolipoprotein E-Deficient Mouse
Aim: The actual occurrence of spontaneous plaque rupture in mice has been a matter of debate. We report on an in vivo observation of the actual event of possible plaque disruption in a living ApoE-/- mouse. Methods and Results: During live …
Publication
Proximal to middle left coronary artery flow velocity ratio, as assessed using color Doppler echocardiography, predicts coronary artery atherosclerosis in mice
BACKGROUND: We aimed to establish a completely noninvasive technique to assess coronary artery atherosclerosis in living mice using proximal to middle left coronary artery (LCA) velocity ratio as assessed with color Doppler echocardiography (CDE). METHODS …