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Quantitative volumetric imaging of normal, neoplastic and hyperplastic mouse prostate using ultrasound
Abstract Background: Genetically engineered mouse models are essential to the investigation of the molecular mechanisms underlying human prostate pathology and the effects of therapy on the diseased prostate. Serial in vivo volumetric imaging expands the …
Publication
Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer
// James Kalmuk 1, 4 , Margaret Folaron 1, 2 , Julian Buchinger 1, 5 , Roberto Pili 3 , Mukund Seshadri 1, 2 1 Department of Pharmacology and Therapeutics, Buffalo, NY, USA 2 Department of Molecular and Cellular Biophysics and Biochemistry, Buffalo, NY, …
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Safety and Chemopreventive Effect of Polyphenon E in Preventing Early and Metastatic Progression of Prostate Cancer in TRAMP Mice.
Prostate cancer treatment is often accompanied by untoward side effects. Therefore, chemoprevention to reduce the risk and inhibit the progression of prostate cancer may be an effective approach to reducing disease burden. We investigated the safety and …
Publication
CHARACTERIZATION OF THYROID CANCER IN MOUSE MODELS USING HIGH-FREQUENCY QUANTITATIVE ULTRASOUND TECHNIQUES
Currently, the evaluation of thyroid cancer relies on the use of fine-needle aspiration biopsy, as noninvasive imaging methods do not provide sufficient levels of accuracy for the diagnosis of this disease. In this study, the potential of quantitative …
Publication
Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice
BACKGROUND: To evaluate whether Contrast Enhanced Ultrasund (CEUS) with microbubbles (MBs) targeted to VEGFR-2 is able to characterize in vivo the VEGFR-2 expression in the tumor vasculature of a mouse model of thyroid cancer (Tg-TRK-T1). METHODS: Animal …
Publication
p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer
Anaplastic thyroid carcinoma (ATC) has among the worst prognoses of any solid malignancy. The low incidence of the disease has in part precluded systematic clinical trials and tissue collection, and there has been little progress in developing effective …
Publication
Preclinical Pharmacologic Evaluation of Pralatrexate and Romidepsin Confirms Potent Synergy of the Combination in a Murine Model of Human T-cell Lymphoma
Purpose:T-cell lymphomas (TCLs) are aggressive diseases, which carry a poor prognosis. The emergence of new drugs for TCL has created a need to survey these agents in a rapid and reproducible fashion, in order to prioritize combinations which should be …
Publication
Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of Echocardiograph
Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with the European Association of …
Publication
Breast Cancer Detection by B7-H3-Targeted Ultrasound Molecular Imaging
Ultrasound is a complimentary imaging modality to mammography in breast cancer detection in particular in patients with dense breast tissue, but is limited by its low diagnostic accuracy. Molecularly-targeted contrast-enhanced ultrasound with microbubbles …
Publication
High-resolution ultrasonography of the cutaneous nerve branches in the hand and wrist
Ultrasonography can be used in the diagnosis of various neuropathies, including nerve injury. Nerves often involved in traumatic and iatrogenic injury are small cutaneous branches in the hand and wrist, which cannot be seen in detail using current …