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MMP-2 and MMP-9 contribute to the angiogenic effect produced by hypoxia/15-HETE in pulmonary endothelial cells
Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are the predominant gelatinases in the developing lung. Studies have shown that the expression of MMP-2 and MMP-9 is upregulated in hypoxic fibroblasts, 15-hydroxyeicosatetraenoic …
Publication
Deletion of Rap1b, but not Rap1a or Epac1, reduces PKA-mediated thyroid cancer
Background: Thyroid cancer is an emerging health problem in the United States and Worldwide. With incidence rates of thyroid cancer rapidly rising, the need to develop new treatment options is becoming a priority and understanding the molecular mechanisms …
Publication
Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging
Heart disease is the leading cause of hospitalization and death worldwide, severely affecting health care costs. Aging is a significant risk factor for heart disease and the senescent heart is characterized by structural and functional changes including …
Publication
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice
Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues, including atherosclerotic lesions, and frequently mediate proinflammatory changes1. Because OxPL are mostly the products of non-enzymatic lipid peroxidation, mechanisms …
Publication
Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
Diminished growth factor signaling improves longevity in laboratory models, while a reduction in the somatotropic axis is favorably linked to human aging and longevity. Given the conserved role of this pathway on lifespan, therapeutic strategies, such as …
Publication
Bone marrow-derived mononuclear cell seeded bioresorbable vascular graft improves acute graft patency by inhibiting thrombus formation via platelet adhesion
Background: Acute thrombosis is a crucial cause of bioresorbable vascular graft (BVG) failure. Bone marrow-derived mononuclear cell (BM-MNC)-seeded BVGs demonstrated high graft patency, however, the effect of seeded BM-MNCs against thrombosis remains to …
Publication
Ultra-high frequency ultrasound in planning capillary perforator flaps: Preliminary experience☆
Ultra-high frequency ultrasound in planning capillary perforator flaps: Preliminary experience☆ …
Publication
Multi-scale Structure-Function Relationships in Right Ventricular Failure Due to Pressure Overload
Right ventricular failure (RVF) is the major cause of death in pulmonary hypertension. Recent studies have characterized changes in RV structure in RVF, including hypertrophy, fibrosis and abnormalities in mitochondria. Few if any studies have explored …
Publication
The oncolytic Adenovirus XVir-N-31 as a novel therapy in muscle-invasive bladder cancer
Muscle‐invasive bladder cancer represents approximately 25% of patients diagnosed with bladder cancer and carries a significant risk of death. Oncolytic viruses (OV) are novel antitumor agents with the ability to selectively replicate and lyse tumor cells …
Publication
Naringenin inhibits NG‑nitro‑L‑arginine methyl ester‑induced hypertensive left ventricular hypertrophy by decreasing angiotensin‑converting enzyme 1 expression
Naringenin (NGN) is a natural flavonoid that exerts antiinflammatory, antioxidant and cardioprotective effects. The present study investigated the effects of NGN on left ventricular hypertrophy in rats with NG -nitro-L-arginine methyl ester …