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Publication
Comparison of velocity vector imaging echocardiography with magnetic resonance imaging in mouse models of cardiomyopathy
BACKGROUND: Myocardial strain imaging using echocardiography can be a cost-effective method to quantify ventricular wall motion objectively, but few studies have compared strain measured with echocardiography against magnetic resonance imaging (MRI) in …
Publication
High-frequency speckle tracking echocardiography in the assessment of left ventricular function and remodeling after murine myocardial infarction
The objectives of this study were to assess the feasibility and accuracy of high-frequency speckle tracking echocardiography (STE) in a murine model of myocardial infarction (MI). STE is used clinically to quantify global and regional cardiac function, …
Publication
In vivo imaging reveals an essential role of vasoconstriction in rupture of the ovarian follicle at ovulation
Rupture of the ovarian follicle releases the oocyte at ovulation, a timed event that is critical for fertilization. It is not understood how the protease activity required for rupture is directed with precise timing and localization to the outer surface, …
Publication
Acoustic cavitation-based monitoring of the reversibility and permeability of ultrasound-induced blood-brain barrier opening
Cavitation events seeded by microbubbles have been previously reported to be associated with MR- or fluorescent-contrast enhancement after focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening. However, it is still unknown whether bubble …
Publication
4,4′-Methylenedianiline Alters Serotonergic Transport in a Novel, Sex-Specific Model of Pulmonary Arterial Hypertension in Rats
Pulmonary arterial hypertension (PAH) is a cardiovascular disorder characterized by elevated pulmonary artery pressure as a result of arterial wall thickening. Patients are 3-4 times more likely to be women than men. This gender discrepancy demonstrates a …
Publication
Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd - Skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis
Many genes, including odd-skipped related 1 (Osr1), are involved in regulation of mammalian kidney development. We describe here a new recessive mutation (kidney adysplasia and variable hydronephrosis, kavh) in the mouse that leads to downregulation of …
Publication
Assessment of ischaemia-reperfusion injury in the mice testis by using contrast ultrasound molecular imaging
Timely diagnosis of ischaemia–reperfusion (IR)-induced injury after testicular torsion may be critical for saving reproductive function. The purpose of this study was to detect IR-induced injury, indicated by E-selectin overexpression, in murine testis …
Publication
Age-related vascular gene expression profiling in mice
Increasing age involves a number of detrimental changes in the cardiovascular system and particularly on the large arteries. It deteriorates vascular integrity and leads to increased vascular stiffness entailing hypertension with increased cardiovascular …
Publication
Assessment of Venous Thrombosis in Animal Models
Deep vein thrombosis and common complications, including pulmonary embolism and post-thrombotic syndrome, represent a major source of morbidity and mortality worldwide. Experimental models of venous thrombosis have provided considerable insight into the …
Publication
Evaluation of Quantitative Imaging Biomarkers in the DSS Colitis Model
Purpose: In humans, colonoscopy is the gold standard for the diagnosis of inflammatory changes of the colon wall. Aim of this study was the identification of less invasive imaging biomarkers in the dextran sodium sulfate (DSS) colitis model to provide …