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Squamous Cell Carcinoma Xenografts: Use of VEGFR2-targeted Microbubbles for Combined Functional and Molecular US to Monitor Antiangiogenic Therapy Effects
Purpose: To assess the ability of vascular endothelial growth factor receptor type 2 (VEGFR2)-targeted and nontargeted ultrasonography (US) to depict antiangiogenic therapy effects and to investigate whether first-pass kinetics obtained with VEGFR2- …
Publication
A New Acute Impact-Compression Lumbar Spinal Cord Injury Model in the Rodent
Traumatic injury to the lumbar spinal cord results in complex central and peripheral nervous tissue damage causing significant neurobehavioural deficits and personal/social adversity. Although lumbar cord injuries are common in humans, there are few …
Publication
Ascending Aortic Aneurysm in Angiotensin II-Infused Mice: Formation, Progression, and the Role of Focal Dissections.
OBJECTIVE To understand the anatomy and physiology of ascending aortic aneurysms in angiotensin II-infused ApoE(-/-) mice. APPROACH AND RESULTS We combined an extensive in vivo imaging protocol (high-frequency ultrasound and contrast-enhanced …
Publication
Axl modulates immune activation of smooth muscle cells in vein graft remodeling.
The pathophysiological mechanisms of the immune activation of smooth muscle cells are not well understood. Increased expression of Axl, a receptor tyrosine kinase, was recently found in arteries from patients after coronary bypass grafts. In the present …
Publication
Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis.
Venous thromboembolism (VTE) is a common complication of cancer. Based on recent evidence that (i) Gas6 regulates the expression of tissue factor during venous thrombosis and (ii) cancer promotes a pro-coagulant milieu, we hypothesize that Gas6 may be …
Publication
Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive MiceSignificance
Objective—Hypercholesterolemia and hypertension are associated with aortic valve stenosis (AVS) in humans. We have examined aortic valve function, structure, and gene expression in hypercholesterolemic/hypertensive mice. Approach and Results—Control, …
Publication
Photodynamic Therapy Synergizes with Irinotecan to Overcome Compensatory Mechanisms and Improve Treatment Outcomes in Pancreatic Cancer
The ability of tumor cells to adapt to therapeutic regimens by activating alternative survival and growth pathways remains a major challenge in cancer therapy. Therefore, the most effective treatments will involve interactive strategies that target …
Publication
Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents : considerations on experimental outcomes and animal welfare
Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents : considerations on experimental outcomes and animal …
Publication
Compatibility of a Novel Thrombospondin-1 Analog with Fertility and Pregnancy in a Xenograft Mouse Model of Endometriosis
Endometriosis is a gynecological disease defined by the growth of endometrium outside of the uterus. Although endometriosis contributes to 50% of female infertility cases, medical treatments are incompatible with pregnancy. Angiogenesis, the growth of …
Publication
Transplacental sildenafil rescues lung abnormalities in the rabbit model of diaphragmatic hernia
Introduction The management of congenital diaphragmatic hernia (DH) would benefit from an antenatal medical therapy, which addresses both lung hypoplasia and persistent pulmonary hypertension. We aimed at evaluating the pulmonary effects of sildenafil in …