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Active curcumin nanoparticles formed from a volatile microemulsion template
Mitochondria targeted phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has excelled as an effective approach among other non-specific techniques for its high selectivity, non-invasiveness and low systemic toxicity. …
Publication
Aldolase promotes the development of cardiac hypertrophy by targeting AMPK signaling
Metabolic dysfunction is a hallmark of cardiac hypertrophy and heart failure. During cardiac failure, the metabolism of cardiomyocyte switches from fatty acid oxidation to glycolysis. However, the roles of key metabolic enzymes in cardiac hypertrophy are …
Publication
Biomimetic O 2 -Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor
Improving the supply of O2 and the circulation lifetime of photosensitizers for photodynamic therapy (PDT) in vivo would be a promising approach to eliminate hypoxic tumors. Herein, by taking advantage of the significant gas-adsorption capability of …
Publication
Cardiovascular effects of cisapride and prucalopride on human 5-HT4 receptors in transgenic mice
Cisapride and prucalopride act as 5-HT4 receptor agonists. As a part of our ongoing effort to study the utility of a transgenic (TG) mouse model overexpressing cardiac 5-HT4 receptors, we assessed the extent to which we could recapitulate cisapride and …
Publication
Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left ‑ ventricular remodeling after acute myocardial infarction : involvement in oxidative stress and apoptosis
Asymmetric dimethylarginine (ADMA) is a risk factor for heart diseases. Dimethylarginine dimethylaminohydrolase (DDAH) enzymes are key proteins for ADMA degradation. Endothelial DDAH1 is a vital regulator of angiogenesis. DDAH1 is also expressed in …
Publication
The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice
Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in elderly people. Increased expression of tumor suppressor protein 53 (p53) has been implicated in vascular senescence. Here, we examined the importance of endothelial p53 for …
Publication
An essential role for Wnt/β-catenin signaling in mediating hypertensive heart disease
Activation of the renin-angiotensin system (RAS) is associated with hypertension and heart disease. However, how RAS activation causes cardiac lesions remains elusive. Here we report the involvement of Wnt/β-catenin signaling in this process. In rats with …
Publication
Multimodality cellular and molecular imaging of concomitant tumour enhancement in a syngeneic mouse model of breast cancer metastasis
Multimodality cellular and molecular imaging of concomitant tumour enhancement in a syngeneic mouse model of breast cancer metastasis …
Publication
Bio-ink properties and printability for extrusion printing living cells
Angiogenesis is a common pathological characteristic of many solid tumors and vulnerable atherosclero- tic plaques. Photothermal therapy (PTT) is a promising method to reduce neovascularization. To increase the targeting ability and efficiency of PTT, a …
Publication
Development of Citrate-Based Dual-Imaging Enabled Biodegradable Electroactive Polymers
Increasing occurrences of degenerative diseases, defective tissues, and severe cancers heighten the importance of advanced biomedical treat- ments, which in turn enhance the need for improved biomaterials with versatile theranostic functionalities yet …