Search
Publication
Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain.
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by slow progression of multiple cysts in both kidneys that lead to renal insufficiency in mid-life or later. ADPKD is associated with mutations mainly in the PKD1 gene (encoding …
Publication
Effect of Sodium-Glucose Cotransport Inhibition on Polycystic Kidney Disease Progression in PCK Rats
The sodium-glucose-cotransporter-2 (SGLT2) inhibitor dapagliflozin (DAPA) induces gluco- suria and osmotic diuresis via inhibition of renal glucose reabsorption. Since increased di- uresis retards the progression of polycystic kidney disease (PKD), we …
Publication
Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations to PKD1 or PKD2, triggering progressive cystogenesis and typically leading to end-stage renal disease in midlife. The phenotypic spectrum, however, ranges from in utero onset to …
Publication
Pathogenesis of Renal Injury in the Megabladder Mouse: A Genetic Model of Congenital Obstructive Nephropathy
Congenital obstructive nephropathy (CON) is the most common cause of chronic renal failure in children, often leading to end stage renal disease. The megabladder (mgb) mouse exhibits signs of urinary tract obstruction progressive renal failure following …
Publication
High-resolution ultrasound biomicroscopy for monitoring ovarian structures in mice
BACKGROUND: Until recently, the limit of spatial resolution of ultrasound systems has prevented characterization of structures /= 20 microns develop in a wave-like fashion. CONCLUSION: The mouse is a suitable model for the study of ovarian dynamics using …
Publication
Tumor development, growth characteristics and spectrum of genetic aberrations in the TH-MYCN mouse model of neuroblastoma.
BACKGROUND: The TH-MYCN transgenic neuroblastoma model, with targeted MYCN expression to the developing neural crest, has been used to study neuroblastoma development and evaluate novel targeted tumor therapies.\n\nMETHODS: We followed tumor development …
Publication
A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies
Neuroblastoma, a childhood cancer that originates from neural crest-derived cells, is the most common deadly solid tumor of infancy. Amplification of the MYCN oncogene, which occurs in approximately 20–25% of human neuroblastomas, is the most prominent …
Publication
A comparison between detectors of high frequency oscillations
Objective—High frequency oscillations (HFOs) are a biomarker of epileptogenicity. Visual marking of HFOs is highly time-consuming and inevitably subjective, making automatic detection necessary. We compare four existing detectors on the same dataset. …
Publication
Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma
Disabling the function of immune checkpoint molecules can unlock T-cell immunity against cancer, yet despite remarkable clinical success with monoclonal antibodies (mAb) that block PD-1 orCTLA-4, resistance remains common and essentially unex- plained. To …
Publication
Use of ultrasound biomicroscopy to evaluate induced ovarian follicular growth and ovulation in mice.
Recent advances in image technology, including significant gains in spatial resolution, have made realtime sequential ovarian evaluations possible in small rodents, allowing longitudinal (continued) studies of the ovarian cycle and reducing the required …