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BET-inhibition by JQ1 alleviates streptozotocin-induced diabetic cardiomyopathy
Diabetic cardiomyopathy is a cascade of complex events leading to eventual heart failure in diabetes. JQ1, one of Bromodomain and extra-terminal domain (BET) protein inhibitors, has exerted therapeutic effects on cancer proliferation, inflammation and …
Publication
Luteolin ameliorates rat myocardial ischemia-reperfusion injury through peroxiredoxin II activation
BACKGROUND AND PURPOSE Antioxidants provide a promising therapeutic effect for the cardiovascular disease. Luteolin (LUT), a polyphenolic bioflavonoid, is known to confer cardioprotection, although the underlying mechanism, especially the role of LUT on …
Publication
Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease.
Kawasaki disease (KD), which is the leading cause of pediatric heart disease, is characterized by coronary vasculitis and subsequent aneurysm formation. Although intravenous immunoglobulin therapy is effective for reducing aneurysm formation, a certain …
Publication
Superselective Drug Delivery Using Doxorubicin-Encapsulated Liposomes and Ultrasound in a Mouse Model of Lung Metastasis Activation
Conventional treatment of lymph node metastasis involves dissection of the tumor and regional lymph nodes, but this may cause activation of latent metastatic tumor cells. However, there are few reports on animal models regarding the activation of latent …
Publication
JDP2 overexpression provokes cardiac dysfunction in mice
The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing mice, to clarify the …
Publication
An Easy-to-Fabricate Clearable CuS-Superstructure-Based Multifunctional Theranostic Platform for Efficient Imaging Guided Chemo-Photothermal Therapy
Despite drug delivery systems (DDSs) have been receiving ever-increasing attention, development of a simple, effective, sensitive and clearable drug delivery and multifunctional theranostic nanoplatform for cancer therapy is still highly desirable and …
Publication
Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats
BACKGROUND Heart failure is associated with altered gene expression and DNA methylation. De novo DNA methylation is associated with gene silencing, but its role in cardiac pathology remains incompletely understood. We hypothesized that inhibition of DNA …
Publication
High birth weight was associated with increased radial artery intima thickness but not with other investigated cardiovascular risk factors in adulthood
Aim This study investigated whether a high birth weight was associated with increased risk factors for cardiovascular disease when Swedish adults reached 34-40. Methods We studied 27 subjects born at Uppsala University Hospital in 1975-1979, weighing at …
Publication
Treatment of SEC62 over-expressing tumors by Thapsigargin and Trifluoperazine
Treatment with analogues of the SERCA-inhibitor Thapsigargin is a promising new approach for a wide variety of cancer entities. However, our previous studies on various tumor cells suggested resistance of SEC62 over-expressing tumors to this treatment. …
Publication
Extracellular signal-regulated kinase (ERK) activation preserves cardiac function in pressure overload induced hypertrophy
Background: Chronic pressure overload and a variety ofmediators induce concentric cardiac hypertrophy.When prolonged, cardiac hypertrophy culminates in decreasedmyocardial function and heart failure. Activation of the extracellular signal-regulated kinase …