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Intrauterine adhesions assessment by photoacoustic imaging versus high frequency ultrasound imaging in rats
Objective: To compare the sensitivity of photoacoustic imaging (PAI) in the detection of Intrauterine adhesions (IUA) at different grades with that of high frequency ultrasound (US), and to investigate whether PAI can evaluate IUA noninvasively and …
Publication
Are we ready to use ultrasounds in the clinical assessment of depth of invasion and tumor thickness in oral squamous cell carcinoma? Results from a systematic review, meta-analysis and trial sequential analysis
Objectives: To investigate the accuracy of ultrasound in the quantification of tumor thickness (TT) and depth of invasion (DOI) of oral potentially malignant disorders and oral squamous cell carcinoma. Materials and methods: A systematic review search was …
Publication
Deficiency of endothelial TRPV4 cation channels ameliorates experimental abdominal aortic aneurysm
Background: Abdominal aortic aneurysm (AAA), albeit usually asymptomatic, is highly lethal if ruptured. The 28-member transient receptor potential (TRP) ion channel superfamily, most of which are present in the aortic cells, is understudied in AAA. We aim …
Publication
Quantitative pharmacodynamics functional evaluation of Chinese medicine Qizhu formula in mice with dynamic near-infrared photoacoustic imaging
Background & Aims: Effective anti-fibrotic drugs and new non-invasive evaluation methods for liver fibrosis (LF) are urgently needed. Our study aimed to evaluate the histological effects of the Qizhu (QZ) formula on LF and to explore a non-invasive …
Publication
Polydopamine Nanobowl-Armoured Perfluorocarbon Emulsions: Tracking Thermal- and Photothermal-Induced Phase Change through Neutron Scattering
Anisotropic polydopamine nanobowls (PDA NBs) show significant promise in biomedicine, distinguished by their unique optical properties and superior cellular uptake compared to spherical nanoparticles. This study presents a novel approach for creating …
Publication
A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer
Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate …
Publication
A P P L I E D S C I E N C E S A N D E N G I N E E R I N G Dormancy-inducing 3D engineered matrix uncovers mechanosensitive and drug-protective FHL2-p21 signaling axis
Solid cancers frequently relapse with distant metastasis, despite local and systemic treatment. Cellular dormancy has been identified as an important mechanism underlying drug resistance enabling late relapse. Therefore, relapse from invisible, minimal …
Publication
Hemodynamic disturbance and mTORC1 activation: Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome
Thoracic aortic aneurysm (TAA) significantly endangers the lives of individuals with Marfan syndrome (MFS), yet the intricacies of their biomechanical origins remain elusive. Our investigation delves into the pivotal role of hemodynamic disturbance in the …
Publication
Western diet promotes endometriotic lesion growth in mice and induces depletion of Akkermansia muciniphila in intestinal microbiota
Background: Endometriosis, affecting 10% of women in their reproductive years, remains poorly understood. Both individual and environmental unexplained factors are implicated in this heterogenous condition. This study aims to examine the influence of a …
Publication
Protease activated receptor 2 deficiency retards progression of abdominal aortic aneurysms by modulating phenotypic transformation of vascular smooth muscle cells via ERK signaling
Abdominal aortic aneurysm (AAA) is characterized by localized structural deterioration of the aortic wall, leading to progressive dilatation and rupture. Protease activated receptor 2 (PAR2) dependent signaling has been implicated in the pathophysiology …