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Publication
Bioluminescence and photoacoustic dual-modality imaging of apoptosis using a duramycin-immobilized gold nanorod probe
Phosphatidylethanolamine (PE) translocation is considered a hallmark event of cellular apoptosis. The development of non-invasive multi-modality probes targeting PE for apoptosis detection holds great promise. Here, we develop a dual-modality imaging …
Publication
Pre-transplant kidney quality evaluation using photoacoustic imaging during normothermic machine perfusion
Due to the shortage of kidneys donated for transplantation, surgeons are forced to use the organs with an elevated risk of poor function or even failure. Although the existing methods for pre-transplant quality evaluation have been validated over decades …
Publication
Nuclear factor of activated T-cells 5 is indispensable for a balanced adaptive transcriptional response of lung endothelial cells to hypoxia
Aims: Chronic hypoxia causes detrimental structural alterations in the lung, which may cause pulmonary hypertension and are partially mediated by the endothelium. While its relevance for the development of hypoxia-associated lung diseases is well known, …
Publication
Effects of moderate doses of ionizing radiation on experimental abdominal aortic aneurysm
Background Exposure to ionizing radiation has been linked to cardiovascular diseases. However, the impact of moderate doses of radiation on abdominal aortic aneurysm (AAA) remains unknown. Methods Angiotensin II-infused Apoe-/- mice were irradiated …
Publication
Low-dose radiation promotes high-fat diet-induced atherosclerosis by activating cGAS signal pathway
Background: Atherosclerosis (AS) is the most prevalent cardiovascular disease, with an exceptionally high burden. High-fat diet (HFD) is a popular diet behavior, whereas low-dose radiation (LDR) is an environmental physical factor. There is evidence to …
Publication
19F MRI/CEUS Dual Imaging-Guided Sonodynamic Therapy Enhances Immune Checkpoint Blockade in Triple-Negative Breast Cancer
Treatment of highly aggressive triple-negative breast cancer (TNBC) in the clinic is challenging. Here, a liposome nanodrug (LP@PFH@HMME) integrating imaging agents and therapeutic agents for bimodal imaging-guided sonodynamic therapy (SDT) is developed, …
Publication
Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer
Muscle invasive bladder cancers (BCs) can be divided into 2 major subgroups-basal/squamous (BASQ) tumors and luminal tumors. Since Pparg has low or undetectable expression in BASQ tumors, we tested the effects of rosiglitazone, Pparg agonist, in a mouse …
Publication
CALCOCO2 prevents AngII-induced atrial remodeling by regulating the interaction between mitophagy and mitochondrial stress
Background: The biological functions of mitochondrial complexes are closely related to the development of atrial fibrillation (AF). Calcium binding and coiled-coil domain 2 (CALCOCO2) is a novel and specific receptor for mitophagy; however, its function …
Resource
September 2025: Vevo Ask The Experts: Cardiovascular Imaging
This is a recording of Vevo Ask The Experts: Cardiovascular Imaging from September 4, 2025. Hosted by Kristiina Aasa, PhD, Product Manager of VisualSonics, and featuring our expert panelists Drew Heinmiller, MSc, Product Manager, Stephen Buttars, MSc, …
Event
EU-Metaheart COST action
The COST Action “EUropean network to tackle METAbolic alterations in HEART failure” (EU-METAHEART) will bring together excellent researchers from Europe to contribute a broad spectrum of scientific expertise, cutting-edge technologies, scientific exchange …