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Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome
Background & Aims: Hepatopulmonary syndrome (HPS) results from portal hypertension, with or without cirrhosis, and is marked by pulmonary vascular dilations leading to severe hypoxemia. Although placental growth factor (PlGF) is important for vascular …
Publication
Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity
Pyroptosis, an immunogenic programmed cell death, could efficiently activate tumor immunogenicity and reprogram immunosuppressive microenvironment for boosting cancer immunotherapy. However, the overexpression of SLC7A11 promotes glutathione biosynthesis …
Publication
Quantitative lung ultrasound findings correlate with radial alveolar count in experimental bronchopulmonary dysplasia
We investigated the relationship between the degree of alveolarization and ultrasound-assessed lung aeration in a validated preterm rabbit model of experimental bronchopulmonary dysplasia (BPD). Lung ultrasound findings were heterogeneously abnormal and …
Publication
Choroid plexus extracellular vesicle transport of blood-borne insulin-like growth factor 1 to the hippocampus of the immature brain
Reduced serum level of insulin-like growth factor 1 (IGF-1), a major regulator of perinatal development, in extremely preterm infants has been shown to be associated with neurodevelopmental impairment. To clarify the mechanism of IGF-1 transport at the …
Publication
Ultrasound-responsive nanocarriers with siRNA and Fe3O4 regulate macrophage polarization and phagocytosis for augmented non-small cell lung cancer immunotherapy
The immunosuppressive tumor microenvironment (TME) significantly inhibits the effective anti-tumor immune response, greatly affecting the efficacy of immunotherapy. Most tumor-associated macrophages (TAMs) belong to the M2 phenotype, which contributes …
Publication
High-fat diet-induced obesity exacerbated collagenase-induced tendon injury with upregulation of interleukin-1beta and matrix metalloproteinase-1
Aims: Obesity increases tendinopathy’s risk, but its mechanisms remain unclear. This study examined the effect of high-fat diet (HFD)-induced obesity on the outcomes and inflammation of collagenase-induced (CI) tendon injury. Methods: Mice were fed with …
Publication
Metformin reverses infertility in a mouse model of endometriosis: unveiling disease pathways and implications for future clinical approaches
Research question: Does metformin reverse endometriosis-associated infertility? Design: Endometriosis was induced by transplanting uterus fragments from B6CBAF1 mice into recipients of the same strain. The mice were divided into groups: endometriosis …
Publication
Engineering Hyperechogenic Colloids with Clot-Targeting Capabilities from Platelet-Derived Membranes
Thrombosis-related cardiovascular diseases remain the leading global cause of mortality and morbidity. In this study, we present a pioneering approach in the field of nanobiotechnology, with a focus on clinical translation, aimed at advancing early …
Publication
An endogenous aryl hydrocarbon receptor ligand induces preeclampsia-like phenotypes in rats
figure legend An endogenous AhR ligand (ITE) elevates maternal blood pressure and proteinuria in pregnant rats, and decreases uteroplacental blood flow and fetal and placental growth, all of which are hallmarks of preeclampsia. ITE also reduces vascular …
Publication
Endometriosis development in relation to hypoxia: a murine model study
Background: Endometriosis, due to its ambiguous symptoms, still remains one of the most difficult female diseases to treat, with an average diagnosis time of 7–9 years. The changing level of hypoxia plays an important role in a healthy endometrium during …