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A Novel Mechanism of Mesenchymal Stromal Cell-Mediated Protection against Sepsis: Restricting Inflammasome Activation in Macrophages by Increasing Mitophagy and Decreasing Mitochondrial ROS
Sepsis, a systemic inflammatory response to infection, is the leading cause of death in the intensive care unit (ICU). Previous studies indicated that mesenchymal stromal cells (MSCs) might have therapeutic potential against sepsis. The current study was …
Publication
Liraglutide protects cardiac function in diabetic rats through the PPAR$α$ pathway.
Increasing evidence shows that diabetes causes cardiac dysfunction.We hypothesized that a glucagon-like peptide-1 (GLP-1) analog, liraglutide, would attenuate cardiac dysfunction in diabetic rats. A total of 24 Sprague--Dawley (SD) rats were divided into …
Publication
Intraoperative imaging of lymphatic vessel using ultra high-frequency ultrasound
Intraoperative imaging of lymphatic vessel using ultra high-frequency ultrasound …
Publication
Imaging Corneal Biomechanical Responses to Ocular Pulse Using High-Frequency Ultrasound
Imaging corneal biomechanical changes or abnormalities is important for better clinical diagnosis and treatment of corneal diseases. We propose a novel ultrasound-basedmethod, called ocular pulse elastography (OPE), to image corneal deformation during the …
Publication
2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy
Numerous experimental studies have supported the evidence that 2-methoxyestradiol (2 ME) is a biologically active metabolite that mediates multiple effects on the cardiovascular system, largely independent of the estrogen receptor. 2 ME is a major …
Publication
Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation
Arterial stiffness plays a causal role in development of systolic hypertension. 20-hydroxyeicosatetraeonic acid (20-HETE), a cytochrome P450 (CYP450)-derived arachidonic acid metabolite, is known to be elevated in resistance arteries in hypertensive …
Publication
Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure
Objective: The study aimed to investigate whether a Shengmai San-derived herbal, Fumai granule (FM), which had a preventive effect on atrial fibrillation (AF) in myocardial infarction (MI)-induced heart failure (HF) rat and to determine the underlying …
Publication
Protein-1 ) in Smooth Muscle Cells Protects Mice From Abdominal Aortic Aneurysms
Abdominal aortic aneurysm (AAA) has high mortality rate when ruptured, but currently, there is no proven pharmacological therapy for AAA because of our poor understanding of its pathogenesis. The current study explored a novel role of smooth muscle cell …
Publication
Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism
Systolic heart failure (heart failure with reduced ejection fraction) manifests as insufficient blood pumping due to contractile dysfunction. Impaired cardiac relaxation also contributes to a form of heart failure termed heart failure with preserved …
Publication
Important Role of Endothelial Caveolin-1 in the Protective Role of EDH against NO-mediated Nitrative Stress in Microcirculation in Mice
AIMS Nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) play important roles in maintaining cardiovascular homeostasis. We have previously demonstrated that endothelial NO synthase (eNOS) plays diverse roles depending on vessel size, as a …