Search
Publication
Combining indocyanine green lymphography and ultrasonography findings to identify lymphatic vessels in advanced-stage lymphedema: The milestone and swirl sign approach
Background: Historically, lymphovenous bypass (LVB) is reserved for patients with early-stage lymphedema owing to the difficulty in identifying functional lymphatic vessels using indocyanine green (ICG) lymphography in patients with advanced lymphedema. …
Publication
Single injection of tacrolimus-loaded thermosensitive hydrogel improves outcomes in vascularized composite allotransplantation
Background: Thermosensitive hydrogels are promising for sustained immunosuppressive drug release, but the efficacy of a single local injection of mixed thermosensitive hydrogel-carried tacrolimus in preventing rejection and maintaining allograft survival …
Publication
An injectable nanocomposite hydrogel with deep penetration ability for enhanced photothermal and chemotherapy
The excessive extracellular matrix (ECM) in solid tumors significantly inhibits the deep penetration and homogeneous distribution of nanodrugs, which greatly reduces the therapeutic efficacy. In the present work, an injectable polyelectrolyte hydrogel …
Publication
The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration
Background: Metabolic syndrome represents a pancreatic ductal adenocarcinoma (PDAC) risk factor. Metabolic alterations favor PDAC onset, which occurs early upon dysmetabolism. Pancreatic neoplastic lesions evolve within a dense desmoplastic stroma, …
Publication
Constructing Intramolecular Electric Fields in NIR-II-Emissive Photosensitizers to Regulate the Local Electron Density for Boosting Hypoxia-Tolerant Cancer Phototheranostics
Constructing Intramolecular Electric Fields in NIR-II-Emissive Photosensitizers to Regulate the Local Electron Density for Boosting Hypoxia-Tolerant Cancer …
Publication
Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma
Osteosarcoma (OS) is the most common primary bone malignancy. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has been implicated in bone destruction, tumor survival and metastases during OS. We examined the role of Dkk-1 in OS disease progression and …
Publication
Left atrial reservoir strain as a predictor of cardiac dysfunction in a murine model of pressure overload
Aim: Left atrial (LA) strain is emerging as a valuable metric for evaluating cardiac function, particularly under pathological conditions such as pressure overload. This preclinical study investigates the predictive utility of LA strain on cardiac …
Publication
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)–LTβ receptor (LTβR) …
Publication
Quantitative ultrasound and photoacoustic assessments of red blood cell aggregation in the human radial artery
We develop concurrent US and photoacoustic (PA) imaging to characterize structural/physiological impact of in-vivo red blood cell (RBC) aggregation. PA images at 700/800/900 nm were collected from the radial arteries of 12 participants across age groups …
Publication
Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy
Multimodal phototheranostics utilizing single molecules offer a “one-and-done” approach, presenting a convenient and effective strategy for cancer therapy. However, therapies based on conventional photosensitizers often suffer from limitations such as a …