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Au-PLGA Hybrid Nanoparticles with Catalase-Mimicking and near-Infrared Photothermal Activities for Photoacoustic Imaging-Guided Cancer Therapy
© 2018 American Chemical Society. Imaging-guided diagnosis and therapy has been highlighted in the area of nanomedicines. However, integrating multiple functions with high performance in one theranostic ("all-in-one") still presents considerable …
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A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart
Chromatin remodelling precedes transcriptional and structural changes in heart failure. A body of work suggests roles for the developmental Wnt signalling pathway in cardiac remodelling. Hitherto, there is no evidence supporting a direct role of Wnt …
Publication
Thyroid Cancer Detection by Ultrasound Molecular Imaging with SHP2-Targeted Perfluorocarbon Nanoparticles
Background . Contrast-enhanced ultrasound imaging has been widely used in the ultrasound diagnosis of a variety of tumours with high diagnostic accuracy, especially in patients with hepatic carcinoma, while its application is rarely reported in thyroid …
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Immune responsive resolvin D1 programs myocardial infarction–induced cardiorenal syndrome in heart failure
Resolvins are innate, immune responsive, bioactive mediators generated after myocardial infarction (MI) to resolve inflammation. The MI-induced bidirectional interaction between progressive left ventricle (LV) remodeling and kidney dysfunction is known to …
Publication
CYP2J2-derived EETs attenuated ethanol-induced myocardial dysfunction through inducing autophagy and reducing apoptosis
Chronic excessive drinking leads to myocardial contractile dysfunction and dilated cardiomyopathy, where ethanol toxicity plays an essential role. Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acids to form epoxyeicosatrienoic acids (EETs), …
Publication
Preoperative measurement of cutaneous melanoma and nevi thickness with photoacoustic imaging
Photoacoustic imaging (PAI) is an emerging biomedical imaging technology, which can potentially be used in the clinic to preoperatively measure melanoma thickness and guide biopsy depth and sample location. We recruited 27 patients with pigmented …
Publication
Kruppel-like factor 15 is required for the cardiac adaptive response to fasting
Cardiac metabolism is highly adaptive in response to changes in substrate availability, as occur during fasting. This metabolic flexibility is essential to the maintenance of contractile function and is under the control of a group of select …
Publication
Repeated administrations of cardiac progenitor cells are superior to a single administration of an equivalent cumulative dose
BACKGROUND We have recently found that 3 repeated doses (12×106each) of c-kitPOScardiac progenitor cells (CPCs) were markedly more effective than a single dose of 12×106cells in alleviating postinfarction left ventricular dysfunction and remodeling. …
Publication
Melatonin attenuated brain death tissue extract-induced cardiac damage by suppressing DAMP signaling
We tested the hypothesis that melatonin prevents brain death (BD) tissue extract (BDEX)-induced cardiac damage by suppressing inflammatory damage-associated molecular pattern (DAMP) signaling in rats. Six hours after BD induction, levels of a DAMP …
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Quercetin Prevents In Vivo and In Vitro Myocardial Hypertrophy Through the Proteasome-GSK-3 Pathway
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose: Quercetin, a flavonoid, has been reported to ameliorate cardiovascular diseases, such as cardiac hypertrophy. However, the mechanism is not completely understood. In this …