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Chemotherapy in synergy with innate immune agonists enhances T cell priming for checkpoint inhibitor treatment in pancreatic cancer
Background: The combination of conventional chemotherapy and immune checkpoint inhibitors (ICIs) has been unsuccessful for pancreatic ductal adenocarcinoma (PDAC). Administration of maximum tolerated dose of chemotherapy drugs may have immunosuppressive …
Publication
Steatohepatitis-induced vascular niche alterations promote melanoma metastasis
Steatohepatitis-induced vascular niche alterations promote melanoma metastasis …
Publication
MARCH5 ameliorates aortic valve calcification via RACGAP1-DRP1 associated mitochondrial quality control
Background: Mitochondrial E3 ubiquitin ligase (MARCH5) as an important regulator in maintaining mitochondrial function. Our aims were to investigate the role and mechanism of MARCH5 in aortic valve calcification. Methods: Human aortic valves, both …
Publication
Non-invasive estimation of left ventricular chamber stiffness using cardiovascular magnetic resonance and echocardiography
Background: Preclinical studies exploring the underlying mechanisms of elevated left ventricular (LV) chamber stiffness play a crucial role in developing new therapeutic strategies. However, there is a lack of systematic evaluation of imaging biomarkers …
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Protocol for studying the superior mesenteric artery in mice using non-invasive micro-ultrasound imaging and anatomic dissection
The superior mesenteric artery (SMA), originating from the abdominal aorta, provides blood supply for the spleen, pancreas, intestine, and part of the colon. Here, we present a protocol for studying the SMA in the same mouse by combining non-invasive …
Publication
Inhibition of ATP-citrate lyase by bempedoic acid protects against abdominal aortic aneurysm formation in mice
Abdominal aortic aneurysm (AAA) is a prevalent degenerative disease characterized by an exacerbated inflammation and destructive vascular remodeling. Unfortunately, effective pharmacological tools for the treatment of this disease remain a challenge. …
Publication
Local characterization of collagen architecture and mechanical properties of tissue engineered atherosclerotic plaque cap analogs
Many cardiovascular events are triggered by fibrous cap rupture of an atherosclerotic plaque in arteries. However, cap rupture, including the impact of the cap's structural components, is poorly understood. To obtain better mechanistic insights in a …
Publication
Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization
Nasopharyngeal carcinoma (NPC), a malignancy highly prevalent in East and Southeast Asia, is primarily treated with radiotherapy (RT). However, hypoxia-induced radioresistance presents a significant challenge. Nanozymes, nanomaterials with catalase-like …
Publication
Ginsenoside RG3 Synergizes With STING Agonist to Reverse Cisplatin Resistance in Gastric Cancer
This study investigates the synergistic inhibitory effects of combining the stimulator of interferon genes (STING) agonist cyclic diadenylate monophosphate (c-di-AMP) and ginsenoside RG3 on cisplatin (DDP)-resistant gastric cancer (GC) cells. The …
Publication
Ultrabright contrast agents with synergistic Raman enhancements for precise intraoperative imaging and photothermal ablation of orthotopic tumor models
Background: Intraoperative imaging is critical for achieving precise cancer resection. Among available techniques, Raman spectral imaging emerges as a promising modality due to its high spatial resolution and signal stability. However, its clinical …