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In vivo analysis of puerarin from Pueraria tuberosa as a promising galactagogue
Breastfeeding is crucial for maternal and infant health, yet global rates vary, with India having the highest at 43.2% and the lowest at 35.8%.To evaluate the galactagogue properties of Pueraria tuberosa in a female rat model, assess its safety through …
Publication
Protocol for generating brain metastatic tumor cells through repeated intracardiac injections in mice
Here, we present a protocol for generating the lung cancer cell line, LLC1-BMT5, with highly brain metastatic tropism through multiple rounds of in vivo selection. We describe steps for establishing the brain metastases (BrMs) mouse model through …
Publication
The Yucatan Minipig: A Reliable Model for Studying Unilateral Vocal Fold Paralysis
Objectives/Hypothesis: Given the complex pathology underlying unilateral vocal fold paralysis (UVFP), there has been limited systematic exploration of curative treatments in humans. Central to the investigation of experimental therapies includes …
Publication
Ablation of Hepatic Asah1 Gene Disrupts Hepatic Lipid Homeostasis and Promotes Fibrotic Nonalcoholic Steatohepatitis in Mice
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of chronic liver conditions, ranging from simple steatosis to nonalcoholic steatohepatitis, which may progress to fibrosis/cirrhosis. Here, the GSE163211 data set was analyzed, and Asah1 …
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Ultrasound nanodroplets loaded with Siglec-G siRNA and Fe3O4 activate macrophages and enhance phagocytosis for immunotherapy of triple-negative breast cancer
Background: The progression of triple-negative breast cancer is shaped by both tumor cells and the surrounding tumor microenvironment (TME). Within the TME, tumor-associated macrophages (TAMs) represent a significant cell population and have emerged as a …
Publication
Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia
Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of body weight occurring in about 80% of cancer patients, frequently representing the leading cause of death. Dietary intervention is emerging as a promising therapeutic …
Publication
A Mitochondria-Targeted Fluorescence/Photoacoustic Dual-Modality imaging probe for Hypochlorous Acid-Related inflammatory Responses in vivo
Hypochlorous acid (HClO) is a crucial endogenous reactive oxygen species (ROS) that is widely regarded as a representative of ROS. The excessive accumulation of HClO has been intimately linked to tissue damage and a myriad of diseases. Notably, …
Publication
Wearable photobiomodulation halts thyroid cancer growth by leveraging thyroid photosensitivity
With papillary thyroid carcinoma (PTC) rates rising significantly, concerns about conventional treatments like thyroidectomy and radiotherapy highlight the need for non-invasive options. Our study explores photobiomodulation therapy (PBMT), which uses …
Publication
Lead-induced actin polymerization aggravates neutrophil extracellular trap formation and contributes to vascular inflammation
Lead (Pb) exposure is widely acknowledged as a risk factor for cardiovascular diseases. Previous studies have established neutrophil involvement in Pb-induced cardiovascular injuries; however, the underlying mechanisms remain unclear. To address this …
Publication
A mitochondria-targeted NIR fluorescence/photoacoustic dual-modality probe for highly sensitive and selective imaging of HClO in vivo
Hypochlorous acid (HClO) represents a typical endogenous reactive oxygen species primarily generated within mitochondria, with excessive levels intimately linked to numerous pathological conditions. Consequently, the detection of mitochondrial HClO in …