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Publication
Electromechanical vortex filaments during cardiac fibrillation
Self-organized dynamics of vortex-like rotating waves or scroll waves underlie complex spatial-temporal pattern formation in many excitable chemical and biological systems1-4. In the heart, filament-like phase singularities5,6associated with …
Publication
Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype
AIMS: Acute myocardial infarction (MI) is the leading cause of mortality worldwide. Anti-inflammatory strategies to reduce neutrophil-driven acute post-MI injury have been shown to limit acute cardiac tissue damage. On the other hand, whether neutrophils …
Publication
Magnetic resonance and photoacoustic imaging of brain tumor mediated by mesenchymal stem cell labeled with multifunctional nanoparticle introduced via carotid artery injection
OBJECTIVE: To evaluate the feasibility of visualizing bone marrow-derived human mesenchymal stem cells (MSCs) labeled with a gold-coated magnetic resonance (MR)-active multifunctional nanoparticle and injected via the carotid artery for assessing the …
Publication
Three-dimensional visualization of extracellular matrix networks during murine development
The extracellular matrix (ECM) plays a crucial role in embryogenesis, serving both as a substrate to which cells attach and as an active regulator of cell behavior. However, little is known about the spatiotemporal expression patterns and 3D structure of …
Publication
Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis
Atherosclerosis is characterized by the accumulation of lipids within the arterial wall. Although activation of TRPV1 cation channels by capsaicin may reduce lipid storage and the formation of atherosclerotic lesions, a clinical use for capsaicin has been …
Publication
Cardiac basal autophagic activity and increased exercise capacity
To investigate whether high-intensity interval training (HIIT) and continuous moderate-intensity training (CMT) have different impacts on exercise performance and cardiac function and to determine the influence of these exercise protocols on modulating …
Publication
CRTH2 promotes endoplasmic reticulum stress‐induced cardiomyocyte apoptosis through m‐calpain
© 2018 EMBO. Apoptotic death of cardiac myocytes is associated with ischemic heart disease and chemotherapy-induced cardiomyopathy. Chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) is highly expressed in the heart. …
Publication
Thermoacoustic Lensing in Ultrasound Imaging of Nonechogenic Tissue During High-intensity Focused Ultrasound Exposure
We develop a ray-tracing theory to describe the effects of thermoacoustic lensing during high-intensity focused ultrasound (HIFU) on ultrasound images of reflectors lying distal to the HIFU focal region and discuss the application of thermal lensing …
Publication
The large-conductance voltage- and Ca 2+ -activated K + channel and its γ1-subunit modulate mouse uterine artery function during pregnancy
The uterine artery (UA) markedly vasodilates during pregnancy to direct blood flow to the developing fetus. Inadequate UA vasodilatation leads to intrauterine growth restriction and fetal death. The large-conductance voltage- and Ca2+ -activated K+ (BKCa …
Publication
Red blood cell antibody-induced anemia causes differential degrees of tissue hypoxia in kidney and brain
Moderate anemia is associated with increased mortality and morbidity, including acute kidney injury (AKI), in surgical patients. A red blood cell (RBC)-specific antibody model was utilized to determine whether moderate subacute anemia could result in …