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Methyleugenol alleviates pulmonary vascular remodeling in rats with high-altitude pulmonary hypertension by improving pulmonary smooth muscle cell function
Pulmonary hypertension is divided into five groups, and chronic exposure to hypoxia causes pulmonary hypertension in the third group – high altitude pulmonary hypertension, which is commonly seen in patients with chronic obstructive pulmonary disease, …
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The use of ultra-high frequency ultrasound in identifying aganglionosis in Hirschsprung’s disease
To make surgery more precise and to shorten anesthesia-times for children undergoing surgery for Hirschsprung’s disease, ultra-high frequency ultrasound (UHFUS) has been suggested to replace peroperative biopsy. The study’s aim was to determine …
Publication
Vascular remodeling in arteriovenous fistula treated with PDE5A inhibitors
The arteriovenous fistula (AVF) is the lifeline for hemodialysis patients. However, there are currently no effective therapies promoting AVF maturation. AVF dilation by smooth muscle cell relaxation, through increased cyclic guanosine monophosphate …
Publication
Two photoacoustic spectral coloring compensation techniques adapted to the context of human in-vivo oxygenation measurements
Photoacoustic imaging can potentially map oxygen saturation (sO 2 ) non-invasively. However, in-vivo human application is challenging due to spectral coloring, which causes a wavelength-dependent fluence attenuation and uncertainty in the estimation of …
Publication
Development of Pd-Loaded Hf-Based Metal-Organic Framework as a Dual-Modal Contrast Agent for Photoacoustic Imaging and Computed Tomography
Noninvasive cancer imaging significantly improves diagnostics by providing comprehensive structural and functional information about tumors. Herein, we explored palladium nanoparticles loaded hafnium-based metal-organic framework (MOF) (Hf-EDB), i.e., …
Publication
Review of Non-Invasive Imaging Technologies for Cutaneous Melanoma
Imaging technologies are constantly being developed to improve not only melanoma diagnosis, but also staging, treatment planning, and disease progression. We start with a description of how melanoma is characterized using histology, and then continue by …
Publication
Osteocalcin deficiency attenuates neointima formation after vascular injury in rat
Osteocalcin deficiency attenuates neointima formation after vascular injury in rat …
Publication
Ultrasound Visualization of Spatiotemporal Autophagy-Regulated Nanodroplets for Amplifying ICB in Melanoma via Remodeling Tumor Inflammatory Microenvironment
Immune checkpoint blockade (ICB) therapy, represented by anti-PD-1/PD-L1 antibodies, is confronted with difficulties of unsatisfied response rates owing to the prevalence of “cold” immune tumor microenvironment (TME) in most cancers. Blocking …
Publication
Impact of kidney function on stiffness of small conduit arteries in hypertension and obesity
Background:Arterial stiffness is a key cardiovascular risk factor influenced by conditions like hypertension, obesity and kidney function. Although large arteries have been extensively studied, small conduit arteries remain less investigated. This study …
Publication
Investigating the presence and detectability of structural peripheral arterial changes in children with well-regulated type 1 diabetes versus healthy controls using ultra-high frequency ultrasound: a single-centre cross-sectional and case-control study
Background: Children with type 1 diabetes have an increased risk of macrovascular complications. This study used ultra-high frequency ultrasound (UHFUS), enabling differentiation of intima thickness (IT), and media thickness (MT) in peripheral arteries, …